Magnetoelectric Nanodiscs Enable Wireless Transgene-Free Neuromodulation.

Autor: Kim YJ; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Driscoll N; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Kent N; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Paniagua EV; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Tabet A; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Koehler F; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Manthey M; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Sahasrabudhe A; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Signorelli L; Department of Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen - Nuremberg, Erlangen, Germany., Gregureć D; Department of Chemistry and Pharmacy, Friedrich-Alexander University of Erlangen - Nuremberg, Erlangen, Germany., Anikeeva P; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 25. Date of Electronic Publication: 2023 Dec 25.
DOI: 10.1101/2023.12.24.573272
Abstrakt: Deep-brain stimulation (DBS) with implanted electrodes revolutionized treatment of movement disorders and empowered neuroscience studies. Identifying less invasive alternatives to DBS may further extend its clinical and research applications. Nanomaterial-mediated transduction of magnetic fields into electric potentials offers an alternative to invasive DBS. Here, we synthesize magnetoelectric nanodiscs (MENDs) with a core-double shell Fe 3 O 4 -CoFe 2 O 4 -BaTiO 3 architecture with efficient magnetoelectric coupling. We find robust responses to magnetic field stimulation in neurons decorated with MENDs at a density of 1 μg/mm 2 despite individual-particle potentials below the neuronal excitation threshold. We propose a model for repetitive subthreshold depolarization, which combined with cable theory, corroborates our findings in vitro and informs magnetoelectric stimulation in vivo. MENDs injected into the ventral tegmental area of genetically intact mice at concentrations of 1 mg/mL enable remote control of reward behavior, setting the stage for mechanistic optimization of magnetoelectric neuromodulation and inspiring its future applications in fundamental and translational neuroscience.
Competing Interests: Competing interests: Y.J.K., F.K. and P.A. have applied for a provisional US patent related to the magnetoelectric nanodisc technology reported in the manuscript.
Databáze: MEDLINE
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