Accelerating patient recruitment using social media: Early adopter experience from a good clinical practice-monitored randomized controlled phase I/IIa clinical trial on actinic keratosis.

Autor:	Ortner VK; Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, DK-2400, Copenhagen, Denmark., Zibert JR; Studies&Me A/S, Copenhagen, Denmark.; Coegin Pharma AB, Lund, Sweden., Budnik O; Studies&Me A/S, Copenhagen, Denmark., Manole I; Studies&Me A/S, Copenhagen, Denmark.; Colentina Clinical Hospital, 2nd Department of Dermatology, Bucharest, Romania., Laugesen CAP; Studies&Me A/S, Copenhagen, Denmark., Havsager S; Studies&Me A/S, Copenhagen, Denmark., Haedersdal M; Department of Dermatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, DK-2400, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Contemporary clinical trials communications [Contemp Clin Trials Commun] 2023 Dec 20; Vol. 37, pp. 101245. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2024).
DOI:	10.1016/j.conctc.2023.101245
Abstrakt:	Background: Patient recruitment is a major cause of delays in randomized controlled trials (RCT). Online recruitment is evolving into an alternative to conventional in-clinic recruitment for RCT. The objective of this study was to test the effectiveness of online patient recruitment for an RCT on actinic keratosis (AK). Methods: In this proof-of-concept study, adults with AK were recruited for a Phase I/IIa RCT (NCT05164393) via social media using targeted advertising Interested users were directed to a landing page to learn about the study, respond to questionnaires, and upload self-obtained smartphone pictures of potential AK. Facebook Analytics was used to track the number of advertisement views, individual users exposed to the advertisement, and advertisement clicks. Following eligibility-review by remote dermatologists, candidates were contacted for an in-clinic visit. A review of pertinent RCTs on AK (2012-2022) was conducted to compare recruitment metrics. Results: The online campaign served 886,670 views, reached 309,000 users, and generated 27,814 clicks. A total of 556 users underwent eligibility review, leading to 140 pre-evaluated potential study subjects. The RCT's enrollment target of 60 patients (68.8 ± 7.1 years, 43.3 % female) was reached in 53 days after screening 90 participants in-clinic, corresponding to a screen failure rate of 33.3 %. The total cost of this online recruitment campaign was 14,285 USD i.e. 238 USD per randomized patient. Compared to the existing literature (44 RCTs), our online approach resulted in 9 times more time-efficient recruitment per site. Conclusion: Using targeted advertisements, 60 patients with AK were recruited for a single-center Phase I/IIa RCT in 53 days. Social media appears to be an efficient platform for online recruitment of patients with low-grade AK for RCT. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. JRZ is a paid consultant to Coegin Pharma AB; OB, SH, and CAPL are employees at S&Me; IM is a paid consultant to S&Me; MH has received a research grant from S&Me. (© 2023 The Authors.)
Databáze:	MEDLINE
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