Synthesis, toxicological and in silico evaluation of novel spiro pyrimidines against Culex pipiens L. referring to chitinase enzyme.
Autor: | Abbass EM; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt. eslammorad@sci.asu.edu.eg., Ali AK; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt., El-Farargy AF; Chemistry Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt., Abdel-Haleem DR; Entomology Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt., Shaban SS; Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, 11566, Cairo, Egypt. |
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Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2024 Jan 17; Vol. 14 (1), pp. 1516. Date of Electronic Publication: 2024 Jan 17. |
DOI: | 10.1038/s41598-024-51771-8 |
Abstrakt: | The exponential development of resistance to conventional chemical insecticides adds another important motive for the creation of novel insecticidal active agents. One of the keys to meeting this challenge is the exploration of novel classes of insecticidal molecules with different modes of action. Herein, a novel series of spiro pyrimidine derivatives was prepared using some green synthetic methodologies such as microwave irradiation, and sonication under ultrasound waves. Spiro pyrimidine aminonitrile 1 is a key starting material for the synthesis of targets 2-9 by reaction with different carbon electrophiles and nitrogen nucleophiles. The structures of all the newly synthesized compounds were approved using spectral data. The toxicological efficiency and biological impacts of the synthesized spiro pyrimidine derivatives were assessed against Culex pipiens L. larvae. The toxicity of synthesized compounds showed remarkable variations against the C. pipiens larvae. Where, 3, 4 and 2 were the most efficient compounds with LC (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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