Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children.

Autor: Pantell MS; Division of Pediatric Hospital Medicine, Department of Pediatrics, University of California, San Francisco, CA, USA. Matt.Pantell@ucsf.edu.; Center for Health and Community, University of California, San Francisco, San Francisco, CA, USA. Matt.Pantell@ucsf.edu.; Social Interventions Research and Evaluation Network, University of California, San Francisco, CA, USA. Matt.Pantell@ucsf.edu., Silveira PP; Douglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.; Ludmer Centre for Neuroinformatics and Mental Health and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada., de Mendonça Filho EJ; Douglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.; Ludmer Centre for Neuroinformatics and Mental Health and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada., Wing H; Center for Health and Community, University of California, San Francisco, San Francisco, CA, USA.; Social Interventions Research and Evaluation Network, University of California, San Francisco, CA, USA., Brown EM; California Policy Lab, Berkeley, CA, USA., Keeton VF; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 490 Illinois St, Box 2930, 94143, San Francisco, CA, USA., Pokhvisneva I; Douglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada., O'Donnell KJ; Douglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.; Ludmer Centre for Neuroinformatics and Mental Health and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Yale Child Study Center & Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA., Neuhaus J; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA., Hessler D; Social Interventions Research and Evaluation Network, University of California, San Francisco, CA, USA.; Department of Family and Community Medicine, University of California, San Francisco, CA, USA., Meaney MJ; Douglas Mental Health University Institute, Douglas Research Center, McGill University, Montreal, QC, Canada.; Ludmer Centre for Neuroinformatics and Mental Health and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore., Adler NE; Center for Health and Community, University of California, San Francisco, San Francisco, CA, USA., Gottlieb LM; Center for Health and Community, University of California, San Francisco, San Francisco, CA, USA.; Social Interventions Research and Evaluation Network, University of California, San Francisco, CA, USA.; Department of Family and Community Medicine, University of California, San Francisco, CA, USA.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 May; Vol. 95 (6), pp. 1553-1563. Date of Electronic Publication: 2024 Jan 17.
DOI: 10.1038/s41390-023-02992-6
Abstrakt: Background: Prior work has found relationships between childhood social adversity and biomarkers of stress, but knowledge gaps remain. To help address these gaps, we explored associations between social adversity and biomarkers of inflammation (interleukin-1β [IL-1β], IL-6, IL-8, tumor necrosis factor-alpha [TNF-α], and salivary cytokine hierarchical "clusters" based on the three interleukins), neuroendocrine function (cortisol, cortisone, dehydroepiandrosterone, testosterone, and progesterone), neuromodulation (N-arachidonoylethanolamine, stearoylethanolamine, oleoylethanolamide, and palmitoylethanolamide), and epigenetic aging (Pediatric-Buccal-Epigenetic clock).
Methods: We collected biomarker samples of children ages 0-17 recruited from an acute care pediatrics clinic and examined their associations with caregiver-endorsed education, income, social risk factors, and cumulative adversity. We calculated regression-adjusted means for each biomarker and compared associations with social factors using Wald tests. We used logistic regression to predict being in the highest cytokine cluster based on social predictors.
Results: Our final sample included 537 children but varied based on each biomarker. Cumulative social adversity was significantly associated with having higher levels of all inflammatory markers and with cortisol, displaying a U-shaped distribution. There were no significant relationships between cumulative social adversity and cortisone, neuromodulation biomarkers or epigenetic aging.
Conclusion: Our findings support prior work suggesting that social stress exposures contribute to increased inflammation in children.
Impact: Our study is one of the largest studies examining associations between childhood social adversity and biomarkers of inflammation, neuroendocrine function, neuromodulation, and epigenetic aging. It is one of the largest studies to link childhood social adversity to biomarkers of inflammation, and the first of which we are aware to link cumulative social adversity to cytokine clusters. It is also one of the largest studies to examine associations between steroids and epigenetic aging among children, and one of the only studies of which we are aware to examine associations between social adversity and endocannabinoids among children.
Clinical Trial Registration: NCT02746393.
(© 2024. The Author(s).)
Databáze: MEDLINE
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