Digital pathology for reporting histopathology samples, including cancer screening samples - definitive evidence from a multisite study.
Autor: | Azam AS; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Tsang YW; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Thirlwall J; Warwick Medical School, University of Warwick, Coventry, UK., Kimani PK; Warwick Medical School, University of Warwick, Coventry, UK., Sah S; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Gopalakrishnan K; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Boyd C; Belfast Health and Social Care Trust, Belfast, UK., Loughrey MB; Belfast Health and Social Care Trust, Belfast, UK.; Queen's University, Belfast, UK., Kelly PJ; Belfast Health and Social Care Trust, Belfast, UK., Boyle DP; Belfast Health and Social Care Trust, Belfast, UK., Salto-Tellez M; Queen's University, Belfast, UK.; Institute for Cancer Research, London, UK., Clark D; Nottingham University Hospital NHS Trust, Nottingham, UK., Ellis IO; Nottingham University Hospital NHS Trust, Nottingham, UK.; University of Nottingham, Nottingham, UK., Ilyas M; Nottingham University Hospital NHS Trust, Nottingham, UK.; University of Nottingham, Nottingham, UK., Rakha E; Nottingham University Hospital NHS Trust, Nottingham, UK.; University of Nottingham, Nottingham, UK., Bickers A; Northern Lincolnshire and Goole NHS Foundation Trust, Scunthorpe, UK., Roberts ISD; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Soares MF; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Neil DAH; Birmingham NHS Foundation Trust, Birmingham, UK., Takyi A; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Raveendran S; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Hero E; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Evans H; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Osman R; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Fatima K; Warwick Medical School, University of Warwick, Coventry, UK., Hughes RW; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., McIntosh SA; Queen's University, Belfast, UK., Moran GW; University of Nottingham, Nottingham, UK., Ortiz-Fernandez-Sordo J; University of Nottingham, Nottingham, UK., Rajpoot NM; Computer Science Department, University of Warwick, Coventry, UK., Storey B; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Ahmed I; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK., Dunn JA; Warwick Medical School, University of Warwick, Coventry, UK., Hiller L; Warwick Medical School, University of Warwick, Coventry, UK., Snead DRJ; University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.; Warwick Medical School, University of Warwick, Coventry, UK.; Computer Science Department, University of Warwick, Coventry, UK. |
---|---|
Jazyk: | angličtina |
Zdroj: | Histopathology [Histopathology] 2024 Apr; Vol. 84 (5), pp. 847-862. Date of Electronic Publication: 2024 Jan 17. |
DOI: | 10.1111/his.15129 |
Abstrakt: | Aims: To conduct a definitive multicentre comparison of digital pathology (DP) with light microscopy (LM) for reporting histopathology slides including breast and bowel cancer screening samples. Methods: A total of 2024 cases (608 breast, 607 GI, 609 skin, 200 renal) were studied, including 207 breast and 250 bowel cancer screening samples. Cases were examined by four pathologists (16 study pathologists across the four speciality groups), using both LM and DP, with the order randomly assigned and 6 weeks between viewings. Reports were compared for clinical management concordance (CMC), meaning identical diagnoses plus differences which do not affect patient management. Percentage CMCs were computed using logistic regression models with crossed random-effects terms for case and pathologist. The obtained percentage CMCs were referenced to 98.3% calculated from previous studies. Results: For all cases LM versus DP comparisons showed the CMC rates were 99.95% [95% confidence interval (CI) = 99.90-99.97] and 98.96 (95% CI = 98.42-99.32) for cancer screening samples. In speciality groups CMC for LM versus DP showed: breast 99.40% (99.06-99.62) overall and 96.27% (94.63-97.43) for cancer screening samples; [gastrointestinal (GI) = 99.96% (99.89-99.99)] overall and 99.93% (99.68-99.98) for bowel cancer screening samples; skin 99.99% (99.92-100.0); renal 99.99% (99.57-100.0). Analysis of clinically significant differences revealed discrepancies in areas where interobserver variability is known to be high, in reads performed with both modalities and without apparent trends to either. Conclusions: Comparing LM and DP CMC, overall rates exceed the reference 98.3%, providing compelling evidence that pathologists provide equivalent results for both routine and cancer screening samples irrespective of the modality used. (© 2024 The Authors. Histopathology published by John Wiley & Sons Ltd.) |
Databáze: | MEDLINE |
Externí odkaz: |