Frequency of Cerebellar Abnormalities Associated With the Differing Magnetic Resonance Imaging Patterns of Term Hypoxic-Ischemic Injury in Children.

Autor: Venkatakrishna SSB; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Sharma P; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Tierradentro-Garcia LO; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Elsingergy M; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Worede F; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Curic J; Graduate MBA Program, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, UK., Alves CAP; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Andronikou S; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: doctor.andronikou@gmail.com.
Jazyk: angličtina
Zdroj: Pediatric neurology [Pediatr Neurol] 2024 Mar; Vol. 152, pp. 73-78. Date of Electronic Publication: 2024 Jan 01.
DOI: 10.1016/j.pediatrneurol.2023.12.023
Abstrakt: Background: We aimed to determine the frequency of cerebellar injury using delayed magnetic resonance imaging (MRI) in children with cerebral palsy, diagnosed with term hypoxic-ischemic injury (HII), and to characterize this for the different MRI patterns of HII.
Methods: We retrospectively reviewed delayed MRI scans in children with cerebral palsy, of whom 1175 had term HII. The pattern of HII was classified into basal ganglia-thalamus (BGT) pattern, watershed (WS) pattern, combined BGT/WS, and multicystic HII. Cerebellar location (hemisphere versus vermis) and the MRI characteristics were documented overall and for each of the different patterns of HII, as well as the association with thalamic injury.
Results: Cerebellar injury was found in 252 of 1175 (21.4%) (median age 6 years [interquartile range: 3 to 9 years]). Of these, 49% (124 of 252) were associated with a BGT pattern, 13% (32 of 252) with a WS pattern, 28% (72 of 252) with a combined BGT/WS pattern, and 10% (24 of 252) with a multicystic pattern. The vermis was abnormal in 83% (209 of 252), and the hemispheres were abnormal in 34% (86 of 252) (with 17% [43 of 252] showing both vermis and hemispheric abnormality).
Conclusions: Over a fifth of patients with cerebral palsy due to HII had a cerebellar abnormality on delayed MRI, most commonly involving the vermis (83%), and as part of a BGT pattern of injury in just under half of these likely reflecting the association of cerebellar vermis injury with profound insults.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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