Genetic history of Cambridgeshire before and after the Black Death.

Autor: Hui R; Alan Turing Institute, London, UK.; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK., Scheib CL; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.; Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.; St John's College, University of Cambridge, Cambridge, UK., D'Atanasio E; Institute of Molecular Biology and Pathology, CNR, Rome, Italy., Inskip SA; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.; School of Archaeology and Ancient History, University of Leicester, Leicester, UK., Cessford C; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.; Cambridge Archaeological Unit, Department of Archaeology, University of Cambridge, Cambridge, UK., Biagini SA; Department of Human Genetics, KU Leuven, Leuven, Belgium., Wohns AW; School of Medicine, Stanford University, Stanford, CA, USA.; Department of Genetics and Biology, Stanford University, Stanford, CA, USA., Ali MQA; Department of Human Genetics, KU Leuven, Leuven, Belgium., Griffith SJ; Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia., Solnik A; Core Facility, Institute of Genomics, University of Tartu, Tartu, Estonia., Niinemäe H; Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia., Ge XJ; Wellcome Genome Campus, Wellcome Sanger Institute, Hinxton, UK., Rose AK; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.; Department of Archaeology, University of Durham, Durham, UK., Beneker O; Department of Human Genetics, KU Leuven, Leuven, Belgium., O'Connell TC; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK., Robb JE; Department of Archaeology, University of Cambridge, Cambridge, UK., Kivisild T; McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.; Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Department of Human Genetics, KU Leuven, Leuven, Belgium.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Jan 19; Vol. 10 (3), pp. eadi5903. Date of Electronic Publication: 2024 Jan 17.
DOI: 10.1126/sciadv.adi5903
Abstrakt: The extent of the devastation of the Black Death pandemic (1346-1353) on European populations is known from documentary sources and its bacterial source illuminated by studies of ancient pathogen DNA. What has remained less understood is the effect of the pandemic on human mobility and genetic diversity at the local scale. Here, we report 275 ancient genomes, including 109 with coverage >0.1×, from later medieval and postmedieval Cambridgeshire of individuals buried before and after the Black Death. Consistent with the function of the institutions, we found a lack of close relatives among the friars and the inmates of the hospital in contrast to their abundance in general urban and rural parish communities. While we detect long-term shifts in local genetic ancestry in Cambridgeshire, we find no evidence of major changes in genetic ancestry nor higher differentiation of immune loci between cohorts living before and after the Black Death.
Databáze: MEDLINE