Dog size and patterns of disease history across the canine age spectrum: Results from the Dog Aging Project.

Autor: Nam Y; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., White M; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, United States of America.; The Broad Institute of Harvard and MIT, Cambridge, MA, United States of America., Karlsson EK; The Broad Institute of Harvard and MIT, Cambridge, MA, United States of America.; Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States of America., Creevy KE; Department of Small Animal Clinical Sciences, Texas A&M University College of Veterinary Medicine & Biomedical Sciences, College Station, TX, United States of America., Promislow DEL; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States of America.; Department of Biology, University of Washington, Seattle, WA, United States of America., McClelland RL; Department of Biostatistics, University of Washington, Seattle, WA, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Jan 17; Vol. 19 (1), pp. e0295840. Date of Electronic Publication: 2024 Jan 17 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0295840
Abstrakt: Age in dogs is associated with the risk of many diseases, and canine size is a major factor in that risk. However, the size patterns are complex. While small size dogs tend to live longer, some diseases are more prevalent among small dogs. In this study we seek to quantify how the pattern of disease history varies across the spectrum of dog size, dog age, and their interaction. Utilizing owner-reported data on disease history from a substantial number of companion dogs enrolled in the Dog Aging Project, we investigate how body size, as measured by weight, associates with the lifetime prevalence of a reported condition and its pattern across age for various disease categories. We found significant positive associations between dog size and the lifetime prevalence of skin, bone/orthopedic, gastrointestinal, ear/nose/throat, cancer/tumor, brain/neurologic, endocrine, and infectious diseases. Similarly, dog size was negatively associated with lifetime prevalence of ocular, cardiac, liver/pancreas, and respiratory disease categories. Kidney/urinary disease prevalence did not vary by size. We also found that the association between age and lifetime disease prevalence varied by dog size for many conditions including ocular, cardiac, orthopedic, ear/nose/throat, and cancer. Controlling for sex, purebred vs. mixed-breed status, and geographic region made little difference in all disease categories we studied. Our results align with the reduced lifespan in larger dogs for most of the disease categories and suggest potential avenues for further examination.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Nam et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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