Preparation of Dinitrogen Trioxide for Organic Synthesis: A Phase Equilibrium Approach.

Autor: Chen Y; Center for Integrated Technology and Organic Synthesis (CiTOS), MolSys Research Unit, University of Liège, B6a, Room 3/19, Allée du Six Août 13, 4000, Liège (Sart Tilman), Belgium., Monbaliu JM; Center for Integrated Technology and Organic Synthesis (CiTOS), MolSys Research Unit, University of Liège, B6a, Room 3/19, Allée du Six Août 13, 4000, Liège (Sart Tilman), Belgium.; WEL Research Institute, Avenue Pasteur 6, 1300, Wavre, Belgium.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Apr 16; Vol. 30 (22), pp. e202303516. Date of Electronic Publication: 2024 Feb 07.
DOI: 10.1002/chem.202303516
Abstrakt: Dinitrogen trioxide (N 2 O 3 ) is a potent nitrosating agent featured with high reactivity and appealing atom economy. Because of its instability and the entanglement of chemical and phase equilibria, N 2 O 3 has rarely been utilized in organic synthesis as a stock reagent with well-defined composition. In this review, the preparations of pure N 2 O 3 and its concentrated solution (>0.1 M) are discussed from the aspect of phase equilibrium. Understanding the physical and chemical characteristics of N 2 O 3 , along with how reaction parameters (temperature, pressure, molar ratio) interact, plays a crucial role in managing the concentration of N 2 O 3 in the liquid phase. This control holds practical significance in achieving quantitative reactions.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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