Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.

Autor:	Jahangir CA; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland., Page DB; Earle A Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA., Broeckx G; Department of Pathology PA2, GZA-ZNA Hospitals, Antwerp, Belgium.; Centre for Oncological Research (CORE), MIPPRO, Faculty of Medicine, Antwerp University, Antwerp, Belgium., Gonzalez CA; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland., Burke C; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland., Murphy C; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland., Reis-Filho JS; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ly A; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Harms PW; Departments of Pathology and Dermatology, University of Michigan, Ann Arbor, MI, USA., Gupta RR; Department of Biomedical Informatics, Stony Brook University, Stony Brook, NY, USA., Vieth M; Institute of Pathology, Klinikum Bayreuth GmbH, Friedrich-Alexander-University Erlangen-Nuremberg, Bayreuth, Germany., Hida AI; Department of Pathology, Matsuyama Shimin Hospital, Matsuyama, Japan., Kahila M; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Kos Z; Department of Pathology and Laboratory Medicine, University of British Columbia, BC Cancer, Vancouver, British Columbia, Canada., van Diest PJ; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.; Johns Hopkins Oncology Center, Baltimore, MD, USA., Verbandt S; Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium., Thagaard J; Technical University of Denmark, Kgs. Lyngby, Denmark.; Visiopharm A/S, Hørsholm, Denmark., Khiroya R; Department of Cellular Pathology, University College Hospital, London, UK., Abduljabbar K; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Acosta Haab G; Hospital Maria Curie, Buenos Aires, Argentina., Acs B; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden., Adams S; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Medicine, NYU Grossman School of Medicine, Manhattan, NY, USA., Almeida JS; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA., Alvarado-Cabrero I; Oncology Hospital, Star Medica Centro, Juarez City, Mexico., Azmoudeh-Ardalan F; Tehran University of Medical Sciences, Tehran, Iran., Badve S; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Winship Cancer Institute, Atlanta, GA, USA., Baharun NB; The National University of Malaysia, Kuala Lumpur, Malaysia., Bellolio ER; Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile., Bheemaraju V; Department of Pathology, Narayana Medical College, Nellore, India., Blenman KR; Department of Internal Medicine Section of Medical Oncology and Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Department of Computer Science, Yale School of Engineering and Applied Science, New Haven, CT, USA., Botinelly Mendonça Fujimoto L; Amazonas Federal University, Manaus, Brazil., Burgues O; Pathology Department, Hospital Cliníco Universitario de Valencia/Incliva, Valencia, Spain., Chardas A; Department of Pathobiology & Population Sciences, The Royal Veterinary College, London, UK., Cheang MCU; Head of Integrative Genomics Analysis in Clinical Trials, ICR-CTSU, Division of Clinical Studies, The Institute of Cancer Research, London, UK., Ciompi F; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Cooper LA; Department of Pathology, Northwestern Feinberg School of Medicine, Chicago, IL, USA., Coosemans A; Department of Oncology, Laboratory of Tumor Immunology and Immunotherapy, KU Leuven, Leuven, Belgium., Corredor G; Biomedical Engineering Department, Emory University, Atlanta, GA, USA., Dantas Portela FL; Hospital Universitário Getúlio Vargas, Manaus, Brazil., Deman F; Department of Pathology PA2, GZA-ZNA Hospitals, Antwerp, Belgium., Demaria S; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.; Department of Pathology, Weill Cornell Medicine, New York, NY, USA., Dudgeon SN; Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Elghazawy M; University of Surrey, Guildford, UK.; Ain Shams University, Cairo, Egypt., Fernandez-Martín C; Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano, HUMAN-tech, Universitat Politècnica de València, Valencia, Spain., Fineberg S; Montefiore Medical Center and the Albert Einstein College of Medicine, New York, NY, USA., Fox SB; Pathology, Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Giltnane JM; Genentech, San Francisco, CA, USA., Gnjatic S; Department of Oncological Sciences, Medicine Hem/Onc, and Pathology, Tisch Cancer Institute - Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gonzalez-Ericsson PI; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Grigoriadis A; Cancer Bioinformatics, Faculty of Life Sciences and Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.; The Breast Cancer Now Research Unit, Faculty of Life Sciences and Medicine, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Halama N; Department of Translational Immunotherapy, German Cancer Research Center, Heidelberg, Germany., Hanna MG; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Harbhajanka A; Case Western University, Cleveland, OH, USA., Hart SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Hartman J; Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden., Hewitt S; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Horlings HM; Division of Pathology, Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands., Husain Z; Praava Health, Dhaka, Bangladesh., Irshad S; King's College London & Guys & St Thomas NHS Trust, London, UK., Janssen EA; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Technology, University of Stavanger, Stavanger, Norway., Kataoka TR; Department of Pathology, Iwate Medical University, Morioka, Japan., Kawaguchi K; Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Khramtsov AI; Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Kiraz U; Department of Pathology, Stavanger University Hospital, Stavanger, Norway.; Department of Chemistry, Bioscience and Environmental Technology, University of Stavanger, Stavanger, Norway., Kirtani P; Histopathology, Aakash Healthcare Super Speciality Hospital, New Delhi, India., Kodach LL; Department of Pathology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands., Korski K; Data, Analytics and Imaging, Product Development, F. Hoffmann-La Roche AG, Basel, Switzerland., Akturk G; Translational Molecular Biomarkers, Merck & Co., Inc., Kenilworth, NJ, USA., Scott E; Translational Medicine, Bristol Myers Squibb, Princeton, NJ, USA., Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Laenkholm AV; Department of Surgical Pathology, Zealand University Hospital, Roskilde, Denmark.; Department of Surgical Pathology, University of Copenhagen, Copenhagen, Denmark., Lang-Schwarz C; Institute of Pathology, Klinikum Bayreuth GmbH, Friedrich-Alexander-University Erlangen-Nuremberg, Bayreuth, Germany., Larsimont D; Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Lennerz JK; Center for Integrated Diagnostics, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Lerousseau M; Centre for Computational Biology (CBIO), Mines Paris, PSL University, Paris, France.; Institut Curie, PSL University, Paris, France.; INSERM U900, Paris, France., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA., Madabhushi A; Department of Biomedical Engineering, Radiology and Imaging Sciences, Biomedical Informatics, Pathology, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Maley SK; NRG Oncology/NSABP Foundation, Pittsburgh, PA, USA., Manur Narasimhamurthy V; Manipal Hospitals, Bangalore, India., Marks DK; Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., McDonald ES; Breast Cancer Translational Research Group, University of Pennsylvania, Philadelphia, PA, USA., Mehrotra R; Indian Cancer Genomic Atlas, Pune, India.; Centre for Health, Innovation and Policy Foundation, Noida, India., Michiels S; Office of Biostatistics and Epidemiology, Gustave Roussy, Oncostat U1018, Inserm, University Paris-Saclay, Ligue Contre le Cancer labeled Team, Villejuif, France., Kharidehal D; Department of Pathology, Narayana Medical College and Hospital, Nellore, India., Minhas FUAA; Tissue Image Analytics Centre, Warwick Cancer Research Centre, PathLAKE Consortium, Department of Computer Science, University of Warwick, Coventry, UK., Mittal S; Department of Chemical Engineering, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA., Moore DA; CRUK Lung Cancer Centre of Excellence, UCL and Cellular Pathology Department, UCLH, London, UK., Mushtaq S; Department of Biochemistry, Ziauddin University, Karachi, Pakistan., Nighat H; Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Raipur, India., Papathomas T; Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.; Department of Clinical Pathology, Drammen Sykehus, Vestre Viken HF, Drammen, Norway., Penault-Llorca F; Service de Pathologie et Biopathologie, Centre Jean PERRIN, INSERM U1240 Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne, Clermont-Ferrand, France., Perera RD; School of Electrical, Mechanical and Infrastructure Engineering, University of Melbourne, Melbourne, Victoria, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Pinard CJ; Radiogenomics Laboratory, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.; Department of Oncology, Lakeshore Animal Health Partners, Mississauga, Ontario, Canada.; Centre for Advancing Responsible and Ethical Artificial Intelligence (CARE-AI), University of Guelph, Guelph, Ontario, Canada., Pinto-Cardenas JC; Diagnostico de Salud Animal SA, Ciudad de México, Mexico., Pruneri G; Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.; Faculty of Medicine and Surgery, University of Milan, Milan, Italy., Pusztai L; Yale Cancer Center, Yale University, New Haven, CT, USA.; Department of Medical Oncology, Yale School of Medicine, Yale University, New Haven, CT, USA., Rajpoot NM; University of Warwick, Coventry, UK., Rapoport BL; The Medical Oncology Centre of Rosebank, Johannesburg, South Africa.; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Rau TT; Institute of Pathology, University Hospital Düsseldorf and Heinrich-Heine-University, Düsseldorf, Germany., Ribeiro JM; Breast Unit, Institute Gustave Roussy, Villejuif, France., Rimm D; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Department of Medicine, Yale University School of Medicine, New Haven, CT, USA., Vincent-Salomon A; Department of Diagnostic and Theranostic Medicine, Institut Curie, University Paris-Sciences et Lettres, Paris, France., Saltz J; Department of Biomedical Informatics, Stony Brook Medicine, New York, NY, USA., Sayed S; Department of Pathology, Aga Khan University, Nairobi, Kenya., Hytopoulos E; Department of Pathology, Aga Khan University, Nairobi, Kenya.; iRhythm Technologies Inc., San Francisco, CA, USA., Mahon S; Mater Misericordiae University Hospital, Dublin, Ireland., Siziopikou KP; Department of Pathology, Section of Breast Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Sotiriou C; Breast Cancer Translational Research Laboratory J.-C. Heuson, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (H.U.B), Université Libre de Bruxelles (ULB), Brussels, Belgium.; Medical Oncology Department, Institut Jules Bordet, Hôpital Universitaire de Bruxelles (H.U.B), Université Libre de Bruxelles (ULB), Brussels, Belgium., Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Centers for Personalized Medicine (ZPM), Heidelberg, Germany., Sughayer MA; King Hussein Cancer Center, Amman, Jordan., Sur D; Department of Medical Oncology, University of Medicine and Pharmacy 'Iuliu Hatieganu', Cluj-Napoca, Romania., Symmans F; University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tanaka S; Kyoto University, Kyoto, Japan., Taxter T; Tempus Labs, Chicago, IL, USA., Tejpar S; Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium., Teuwen J; AI for Oncology Lab, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Thompson EA; Mayo Clinic, Jacksonville, FL, USA., Tramm T; Department of Pathology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark., Tran WT; Department of Radiation Oncology, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Canada., van der Laak J; Head of Integrative Genomics Analysis in Clinical Trials, ICR-CTSU, Division of Clinical Studies, The Institute of Cancer Research, London, UK., Verghese GE; Cancer Bioinformatics, Faculty of Life Sciences and Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK.; The Breast Cancer Now Research Unit, Faculty of Life Sciences and Medicine, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Viale G; Department of Pathology, European Institute of Oncology & University of Milan, Milan, Italy., Wahab N; Tissue Image Analytics Centre, Department of Computer Science, University of Warwick, Coventry, UK., Walter T; Centre for Computational Biology (CBIO), Mines Paris, PSL University, Paris, France.; Institut Curie, PSL University, Paris, France.; INSERM U900, Paris, France., Waumans Y; CellCarta NV, Antwerp, Belgium., Wen HY; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang W; Fudan Medical University Shanghai Cancer Center, Shanghai, PR China., Yuan Y; Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bartlett J; University of Edinburgh, Edinburgh, UK., Loibl S; Department of Medicine and Research, German Breast Group, Neu-Isenburg, Germany., Denkert C; Institut für Pathologie, Philipps-Universität Marburg und Universitätsklinikum Marburg, Marburg, Germany., Savas P; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia., Loi S; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia., Specht Stovgaard E; Department of Pathology, Herlev and Gentofte Hospital, Herlev, Denmark., Salgado R; Department of Pathology PA2, GZA-ZNA Hospitals, Antwerp, Belgium.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Gallagher WM; UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland., Rahman A; UCD School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Jazyk:	angličtina
Zdroj:	The Journal of pathology [J Pathol] 2024 Mar; Vol. 262 (3), pp. 271-288. Date of Electronic Publication: 2024 Jan 17.
DOI:	10.1002/path.6238
Abstrakt:	Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. (© 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.)
Databáze:	MEDLINE
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