Neonatal mortality risk of vulnerable newborns by fine stratum of gestational age and birthweight for 230 679 live births in nine low- and middle-income countries, 2000-2017.

Autor:	Hazel EA; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Erchick DJ; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Katz J; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Lee ACC; Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA., Diaz M; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Wu LSF; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., West KP Jr; Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Shamim AA; BRAC JP Grant School of Public Health, Dhaka, Bangladesh., Christian P; Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ali H; JiVitA Maternal and Child Health Research Project, Rangpur, Bangladesh., Baqui AH; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Saha SK; Child Health Research Foundation, Dhaka, Bangladesh., Ahmed S; Projahnmo Research Foundation, Dhaka, Bangladesh., Roy AD; Projahnmo Research Foundation, Dhaka, Bangladesh., Silveira MF; Post-Graduate Program in Epidemiology-Federal University of Pelotas, Pelotas, Brazil., Buffarini R; Post-Graduate Program in Epidemiology-Federal University of Pelotas, Pelotas, Brazil., Shapiro R; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Zash R; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Kolsteren P; Department of Food Technology, Safety and Health, Ghent University, Ghent, Belgium., Lachat C; Department of Food Technology, Safety and Health, Ghent University, Ghent, Belgium., Huybregts L; Department of Food Technology, Safety and Health, Ghent University, Ghent, Belgium.; Poverty, Health and Nutrition Division, International Food Policy Research Institute, Washington, District of Columbia, USA., Roberfroid D; Namur University, Namur, Belgium.; Belgian Health Care Knowledge Centre, Brussels, Belgium., Zhu Z; Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Centre, Xi'an, China., Zeng L; Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Centre, Xi'an, China., Gebreyesus SH; Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia., Tesfamariam K; Department of Food Technology, Safety, and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium., Adu-Afarwuah S; Department of Nutrition and Food Science, University of Ghana, Accra, Ghana., Dewey KG; Department of Nutrition, Institute for Global Nutrition, University of California, Davis, California, USA., Gyaase S; Kintampo Health Research Centre, Kintampo, Ghana., Poku-Asante K; Kintampo Health Research Centre, Kintampo, Ghana., Boamah Kaali E; Kintampo Health Research Centre, Kintampo, Ghana.; Research and Development Division, Ghana Health Service, Accra, Ghana., Jack D; Columbia University's Mailman School of Public Health, New York, New York, USA., Ravilla T; Aravind Eye Hospital, Madurai, India., Tielsch J; George Washington University Milken Institute School of Public Health, Washington, District of Columbia, USA., Taneja S; Centre for Health Research and Development, Society for Applied Studies, New Delhi, India., Chowdhury R; Centre for Health Research and Development, Society for Applied Studies, New Delhi, India., Ashorn P; Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland., Maleta K; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Ashorn U; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mangani C; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Mullany LC; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Khatry SK; NNIPS, Kathmandu, Nepal., Ramokolo V; HIV and Other Infectious Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.; Gertrude H Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA., Zembe-Mkabile W; Health Systems Research Unit, South African Medical Research Council, Cape Town, South Africa.; College Graduate of Studies, University of South Africa, Pretoria, South Africa., Fawzi WW; Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Wang D; Department of Global and Community Health, College of Public Health, George Mason University, Fairfax, Virginia, USA., Schmiegelow C; Department of Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen, Denmark.; Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark., Minja D; National Institute of Medical Research, Tanga, Tanzania., Msemo OA; National Institute of Medical Research, Tanga, Tanzania., Lusingu JPA; National Institute of Medical Research, Tanga, Tanzania., Smith ER; Department of Global Health, Milken Institute School of Public Health, Washington, District of Columbia, USA., Masanja H; Ifakara Health Institute, Dar es Salaam, Tanzania., Mongkolchati A; ASEAN Institute for Health Development, Mahidol University, Salaya, Thailand., Keentupthai P; College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, Thailand., Kakuru A; Infectious Diseases Research Collaboration, Kampala, Uganda., Kajubi R; Infectious Diseases Research Collaboration, Kampala, Uganda., Semrau K; Ariadne Labs, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Hamer DH; Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.; Section of Infectious Diseases, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA., Manasyan A; University of Alabama at Birmingham, Birmingham, Alabama, USA., Pry JM; Centre for Infectious Disease Research in Zambia, Lusaka, Zambia., Chasekwa B; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe., Humphrey J; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Black RE; International Health Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	BJOG : an international journal of obstetrics and gynaecology [BJOG] 2024 Jan 16. Date of Electronic Publication: 2024 Jan 16.
DOI:	10.1111/1471-0528.17743
Abstrakt:	Objective: To describe the mortality risks by fine strata of gestational age and birthweight among 230 679 live births in nine low- and middle-income countries (LMICs) from 2000 to 2017. Design: Descriptive multi-country secondary data analysis. Setting: Nine LMICs in sub-Saharan Africa, Southern and Eastern Asia, and Latin America. Population: Liveborn infants from 15 population-based cohorts. Methods: Subnational, population-based studies with high-quality birth outcome data were invited to join the Vulnerable Newborn Measurement Collaboration. All studies included birthweight, gestational age measured by ultrasound or last menstrual period, infant sex and neonatal survival. We defined adequate birthweight as 2500-3999 g (reference category), macrosomia as ≥4000 g, moderate low as 1500-2499 g and very low birthweight as <1500 g. We analysed fine strata classifications of preterm, term and post-term: ≥42 ⁺⁰ , 39 ⁺⁰ -41 ⁺⁶ (reference category), 37 ⁺⁰ -38 ⁺⁶ , 34 ⁺⁰ -36 ⁺⁶ ,34 ⁺⁰ -36 ⁺⁶ ,32 ⁺⁰ -33 ⁺⁶ , 30 ⁺⁰ -31 ⁺⁶ , 28 ⁺⁰ -29 ⁺⁶ and less than 28 weeks. Main Outcome Measures: Median and interquartile ranges by study for neonatal mortality rates (NMR) and relative risks (RR). We also performed meta-analysis for the relative mortality risks with 95% confidence intervals (CIs) by the fine categories, stratified by regional study setting (sub-Saharan Africa and Southern Asia) and study-level NMR (≤25 versus >25 neonatal deaths per 1000 live births). Results: We found a dose-response relationship between lower gestational ages and birthweights with increasing neonatal mortality risks. The highest NMR and RR were among preterm babies born at <28 weeks (median NMR 359.2 per 1000 live births; RR 18.0, 95% CI 8.6-37.6) and very low birthweight (462.8 per 1000 live births; RR 43.4, 95% CI 29.5-63.9). We found no statistically significant neonatal mortality risk for macrosomia (RR 1.1, 95% CI 0.6-3.0) but a statistically significant risk for all preterm babies, post-term babies (RR 1.3, 95% CI 1.1-1.5) and babies born at 37 ⁰ -38 ⁶ weeks (RR 1.2, 95% CI 1.0-1.4). There were no statistically significant differences by region or underlying neonatal mortality. Conclusions: In addition to tracking vulnerable newborn types, monitoring finer categories of birthweight and gestational age will allow for better understanding of the predictors, interventions and health outcomes for vulnerable newborns. It is imperative that all newborns from live births and stillbirths have an accurate recorded weight and gestational age to track maternal and neonatal health and optimise prevention and care of vulnerable newborns. (© 2024 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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