Can our microbiome break our hearts? Collaborative production of p -cresol sulfate and indoxyl sulfate by commensal microbes increases susceptibility to thrombosis.
| Autor: | Machado Ribeiro TR; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Brito CB; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Byndloss MX; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA. |
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| Jazyk: | angličtina |
| Zdroj: | MBio [mBio] 2024 Feb 14; Vol. 15 (2), pp. e0269223. Date of Electronic Publication: 2024 Jan 16. |
| DOI: | 10.1128/mbio.02692-23 |
| Abstrakt: | A recent study published in mBio by Nemet et al. revealed the critical role played by two gut microbiota members in producing the metabolites indoxyl sulfate (IS) and p- cresol sulfate ( p CS) (I. Nemet, M. Funabashi,X. S. Li, M. Dwidar, et al., 2023, mBio 14:e01331-23, https://doi.org/10.1128/mbio.01331-23). Understanding microbial pathways leading to IS and p CS production is crucial because they are connected to a pre-thrombotic profile, and having high levels of these metabolites increases the risk of cardiovascular diseases (CVD). Hence, this study can offer vital insights into assessing the risk for CVD and identifying potential treatment targets for this disease. Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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