Vasculitis-Like Hemorrhagic Herpes Zoster and HIV Infections: An Intricate Association.
| Autor: | Cozma EC; Pathophysiology, University of Medicine and Pharmacy of Craiova, Craiova, ROU.; Dermatology, Elias Emergency University Hospital, Bucharest, ROU., Banciu LM; Dermatology, Elias Emergency University Hospital, Bucharest, ROU., Soare C; Dermatology, Elias Emergency University Hospital, Bucharest, ROU., Găman MA; Hematology, Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, ROU.; Hematology, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Voiculescu VM; Dermatology, Elias Emergency University Hospital, Bucharest, ROU.; Dermatology, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Dec 15; Vol. 15 (12), pp. e50609. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.50609 |
| Abstrakt: | Herein, we report the case of a 69-year-old patient who presented to our dermatology clinic for a skin eruption characterized by grouped hemorrhagic vesicles and erosions covered by hemorrhagic crusts on an erythematous background located on the lower right limb. The lesions were small, clustered, and variable in size (diameters between one and 10 mm) and located at the level of the L4-L5 dermatomes. The rash had started three to five days after the complete COVID-19 vaccination scheme with the BNT162b2 Pfizer BioNTech vaccine and had been accompanied by a flu-like syndrome. The histopathological examination established the diagnosis of leukocytoclastic vasculitis potentially in the context of a cytopathic zoster phenomenon. The atypical aspect of the zosterian eruption required additional laboratory work-up to identify possible causes of immunosuppression, i.e., screening for the presence of the human immunodeficiency virus (HIV) infection, solid cancers, as well as measurement of serum immunoglobulin concentrations, which revealed that the subject was HIV-positive. Antiviral treatment was started, with a favorable evolution of the lesions, and the patient was referred to an infectious diseases clinic for initiation of antiretroviral therapy (ART). Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Cozma et al.) |
| Databáze: | MEDLINE |
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