An immersive virtual reality tool for assessing left and right unilateral spatial neglect.

Autor: Thomasson M; Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerland.; Neuropsychology Unit, Neurology Department, University Hospital of Geneva, Geneva, Switzerland.; Cognitive and Experimental Neuropsychology Laboratory, University of Geneva, Geneva, Switzerland., Perez-Marcos D; MindMaze SA, Lausanne, Switzerland., Crottaz-Herbette S; MindMaze SA, Lausanne, Switzerland.; Neuropsychology and Neurorehabilitation Service, Department of Clinical Neurosciences, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland., Brenet F; MindMaze SA, Lausanne, Switzerland., Saj A; Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerland.; Department of Psychology, University of Montréal, Montréal, Quebec, Canada.; CRIR/Institut Nazareth et Louis-Braille du CISSS de la Montérégie-Centre, Longueuil, Quebec, Canada.; Spectre Biotech, Paris, France., Bernati T; Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerland., Serino A; MindMaze SA, Lausanne, Switzerland.; MySpace Lab, Department of Clinical Neurosciences, Lausanne, University of Lausanne, Lausanne, Switzerland.; Laboratory of Cognitive Neuroscience, Neuro-X Institute and Brain-Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland., Tadi T; MindMaze SA, Lausanne, Switzerland., Blanke O; Laboratory of Cognitive Neuroscience, Neuro-X Institute and Brain-Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.; Department of Neurosurgery, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland., Ronchi R; Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerland.; Neuropsychology Unit, Neurology Department, University Hospital of Geneva, Geneva, Switzerland.; Laboratory of Cognitive Neuroscience, Neuro-X Institute and Brain-Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Jazyk: angličtina
Zdroj: Journal of neuropsychology [J Neuropsychol] 2024 Sep; Vol. 18 (3), pp. 349-376. Date of Electronic Publication: 2024 Jan 15.
DOI: 10.1111/jnp.12361
Abstrakt: The reported rate of the occurrence of unilateral spatial neglect (USN) is highly variable likely due to the lack of validity and low sensitivity of classical tools used to assess it. Virtual reality (VR) assessments try to overcome these limitations by proposing immersive and complex environments. Nevertheless, existing VR-based tasks are mostly focused only on near space and lack analysis of psychometric properties and/or clinical validation. The present study evaluates the clinical validity and sensitivity of a new immersive VR-based task to assess USN in the extra-personal space and examines the neuronal correlates of deficits of far space exploration. The task was administrated to two groups of patients with right (N = 28) or left (N = 11) hemispheric brain lesions, also undergoing classical paper-and-pencil assessment, as well as a group of healthy participants. Our VR-based task detected 44% of neglect cases compared to 31% by paper-and-pencil tests in the total sample. Importantly, 30% of the patients (with right or left brain lesions) with no clear sign of USN on the paper-and-pencil tests performed outside the normal range in the VR-based task. Voxel lesion-symptom mapping revealed that deficits detected in VR were associated with lesions in insular and temporal cortex, part of the neural network involved in spatial processing. These results show that our immersive VR-based task is efficient and sensitive in detecting mild to strong manifestations of USN affecting the extra-personal space, which may be undetected using standard tools.
(© 2024 The British Psychological Society.)
Databáze: MEDLINE
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