Thyroid gland: a rare site of metastasis.

Autor: Orlandi AM; Endocrinology Department, Hospital Dr. T. Álvarez, Buenos Aires, Argentina. amorlandi68@gmail.com., Alcaraz G; Endocrinology Department, Hospital Dr. C. Durand, Buenos Aires, Argentina., Bielski L; Endocrinology Department, Sanatorio Güemes, Buenos Aires, Argentina., Brenta G; Endocrinology Department, Unidad Asistencial Dr. C. Milstein, Buenos Aires, Argentina., Jozami LC; Endocrinology Department, Hospital Británico, Buenos Aires, Argentina., Cavallo A; Endocrinology Department Hospital Alta Complejidad, Formosa, Argentina.; Endocrinology Department Hospital Universitario Austral, Buenos Aires, Argentina., Guerra J; Endocrinology Department Hospital Universitario Austral, Buenos Aires, Argentina., Zund S; Head and Neck Surgery Department, Instituto de Oncología A. Roffo, Buenos Aires, Argentina.; Head and Neck Surgery Department Hospital Español de La Plata, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2024 May; Vol. 84 (2), pp. 607-614. Date of Electronic Publication: 2024 Jan 15.
DOI: 10.1007/s12020-023-03626-x
Abstrakt: Purpose: Despite its rich vascularity, metastasis (MTS) to the thyroid tissue is unusual, ranging from 1 to 3%. This entity is not usually considered as differential diagnosis and is not included in the upfront approach in patients with thyroid nodules. Once diagnosed, treatment is controversial. The aim of this study was to evaluate diagnosis, treatment, and outcome at the end of follow-up in patients with a diagnosis of MTS to the thyroid.
Methods: A retrospective multicenter study was designed from 1985 to 2022; 29 patients with MTS to the thyroid gland were included in the analysis.
Results: Clinical presentation included the presence of a nodular goiter (65.5%), compression symptoms (17.2%), diffuse goiter (10.3%), and suspicious lymph nodes in the neck (7%). Primary tumor sites were: kidney (44.8%), breast (24.1%), lung (13.8%), neuroendocrine system (6.9%), colon (3.4%), cervix (3.4%), and ovary (3.4%). In 18/23 patients, suspicious ultrasound criteria for malignancy were described. Preoperative diagnosis was made in 23/27 patients by FNA and confirmed in 18 cases by immunohistochemistry. Seventeen patients underwent surgery. At the end of the follow-up, 19 patients had died of oncological disease, and six were alive (2/6 disease-free with isolated intrathyroidal MTS).
Conclusion: Renal carcinoma was the tumor that most frequently metastasized to the thyroid gland. Immunodiagnosis was a very useful tool for etiological confirmation. Patients with MTS to the thyroid gland as a unique site had a more favorable course compared to patients with multiple metastatic sites. Finally, outcomes and prognosis essentially depended on the biology of the primary tumor.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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