Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size.

Autor:	Duncan MC; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Omondi FH; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Kinloch NN; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Lapointe HR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Speckmaier S; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Moran-Garcia N; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Lawson T; Division of Medical Microbiology and Virology, St. Paul's Hospital, Vancouver, Canada., DeMarco ML; Department of Pathology and Laboratory Medicine, Providence Healthcare, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Simons J; Department of Pathology and Laboratory Medicine, Providence Healthcare, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Holmes DT; Department of Pathology and Laboratory Medicine, Providence Healthcare, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Lowe CF; Division of Medical Microbiology and Virology, St. Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Providence Healthcare, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Bacani N; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Sereda P; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Barrios R; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, Canada., Harris M; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, Canada., Romney MG; Division of Medical Microbiology and Virology, St. Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Providence Healthcare, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Montaner JSG; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Brockman MA; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada., Brumme ZL; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2024 Jul 01; Vol. 38 (8), pp. 1120-1130. Date of Electronic Publication: 2024 Jan 22.
DOI:	10.1097/QAD.0000000000003841
Abstrakt:	Objective: The immunogenic nature of coronavirus disease 2019 (COVID-19) mRNA vaccines led to some initial concern that these could stimulate the HIV reservoir. We analyzed changes in plasma HIV loads (pVL) and reservoir size following COVID-19 mRNA vaccination in 62 people with HIV (PWH) receiving antiretroviral therapy (ART), and analyzed province-wide trends in pVL before and after the mass vaccination campaign. Design: Longitudinal observational cohort and province-wide analysis. Methods: Sixty-two participants were sampled prevaccination, and one month after their first and second COVID-19 immunizations. Vaccine-induced anti-SARS-CoV-2-Spike antibodies in serum were measured using the Roche Elecsys Anti-S assay. HIV reservoirs were quantified using the intact proviral DNA assay; pVL were measured using the cobas 6800 (lower limit of quantification: 20 copies/ml). The province-wide analysis included all 290 401 pVL performed in British Columbia, Canada between 2012 and 2022. Results: Prevaccination, the median intact reservoir size was 77 [interquartile range (IQR): 20-204] HIV copies/million CD4 + T-cells, compared to 74 (IQR: 27-212) and 65 (IQR: 22-174) postfirst and -second dose, respectively (all comparisons P > 0.07). Prevaccination, 82% of participants had pVL <20 copies/ml (max: 110 copies/ml), compared to 79% postfirst dose (max: 183 copies/ml) and 85% postsecond dose (max: 79 copies/ml) ( P  > 0.4). There was no evidence that the magnitude of the vaccine-elicited anti-SARS-CoV-2-Spike immune response influenced pVL nor changes in reservoir size ( P  > 0.6). We found no evidence linking the COVID-19 mass vaccination campaign to population-level increases in detectable pVL frequency among all PWH in the province, nor among those who maintained pVL suppression on ART. Conclusion: We found no evidence that COVID-19 mRNA vaccines induced changes in HIV reservoir size nor plasma viremia. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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