Revitalizing Ancient Mitochondria with Nano-Strategies: Mitochondria-Remedying Nanodrugs Concentrate on Disease Control.

Autor: Long X; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China.; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China., Liu M; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China.; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, P. R. China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China., Nan Y; Geriatric Medical Center, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, 750002, P. R. China., Chen Q; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China.; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, P. R. China., Xiao Z; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China.; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, P. R. China., Xiang Y; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China.; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, P. R. China., Ying X; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China.; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, P. R. China., Sun J; College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, P. R. China., Huang Q; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China., Ai K; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410078, P. R. China.; Hunan Provincial Key Laboratory of Cardiovascular Research, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, P. R. China.; Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, 410078, P. R. China.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 May; Vol. 36 (18), pp. e2308239. Date of Electronic Publication: 2024 Jan 29.
DOI: 10.1002/adma.202308239
Abstrakt: Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad of vital functions across diverse cellular processes. Dysfunctions within mitochondria serve as catalysts for various diseases, prompting widespread cellular demise. Mounting research on remedying damaged mitochondria indicates that mitochondria constitute a valuable target for therapeutic intervention against diseases. But the less clinical practice and lower recovery rate imply the limitation of traditional drugs, which need a further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution and high efficacy by capitalizing on excellent nanomaterials and targeting drug delivery. Mitochondria-remedying nanodrugs have achieved ideal therapeutic effects. This review elucidates the significance of mitochondria in various cells and organs, while also compiling mortality data for related diseases. Correspondingly, nanodrug-mediate therapeutic strategies and applicable mitochondria-remedying nanodrugs in disease are detailed, with a full understanding of the roles of mitochondria dysfunction and the advantages of nanodrugs. In addition, the future challenges and directions are widely discussed. In conclusion, this review provides comprehensive insights into the design and development of mitochondria-remedying nanodrugs, aiming to help scientists who desire to extend their research fields and engage in this interdisciplinary subject.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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