Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS study and review of the literature.

Autor:	Mroczek M; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., de Grado A; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.; Neurophysiology Unit, IRCCS Fondazione Istituto Neurologico 'Carlo Besta', Università degli Studi di Milano, Milano, Italy., Pia H; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., Nochi Z; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Tankisi H; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
Jazyk:	angličtina
Zdroj:	Clinical neurophysiology practice [Clin Neurophysiol Pract] 2023 Dec 12; Vol. 9, pp. 13-20. Date of Electronic Publication: 2023 Dec 12 (Print Publication: 2024).
DOI:	10.1016/j.cnp.2023.12.001
Abstrakt:	Objective: Insufficient sleep is linked to several health problems. Previous studies on the effects of sleep deprivation on cortical excitability using conventional transcranial magnetic stimulation (TMS) included a limited number of modalities, and few inter-stimulus intervals (ISIs) and showed conflicting results. This study aimed to investigate the effects of sleep deprivation on cortical excitability through threshold-tracking TMS, using a wide range of protocols at multiple ISIs. Methods: Fifteen healthy subjects (mean age ± SD: 36 ± 3.34 years) were included. The following tests were performed before and after 24 h of sleep deprivation using semi-automated threshold-tacking TMS protocols: short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) at 11 ISIs between 1 and 30 ms, short interval intracortical facilitation (SICF) at 14 ISIs between 1 and 4.9 ms, long interval intracortical inhibition (LICI) at 6 ISIs between 50 and 300 ms, and short-latency afferent inhibition (SAI) at 12 ISIs between 16 and 30 ms. Results: No significant differences were observed between pre- and post-sleep deprivation measurements for SICI, ICF, SICF, or LICI at any ISIs (p < 0.05). As for SAI, we found a difference at 28 ms (p = 0.007) and 30 ms (p = 0.04) but not at other ISIs. Conclusions: Sleep deprivation does not affect cortical excitability except for SAI. Significance: This study confirms some of the previous studies while contradicting others. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: ‘HT is a shareholder of QTMS Science Ltd., which licences the QTMSG-12 recording protocols used. Other authors have no potential conflict of interest to declare’. (© 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.)
Databáze:	MEDLINE
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