APRI score is not predictive of post-surgical outcomes in cholangiocarcinoma patients.

Autor:	Aslam FN; Alix School of Medicine, Mayo Clinic, Scottsdale, AZ, USA (Faaiq N. Aslam, Tristan A. Loveday)., Loveday TA; Alix School of Medicine, Mayo Clinic, Scottsdale, AZ, USA (Faaiq N. Aslam, Tristan A. Loveday)., Junior PLSU; Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ, USA (Pedro Luiz Serrano Uson Junior, Tanios Bekaii-Saab, Mitesh J. Boarad).; Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil (Pedro Luiz Serrano Uson Junior)., Truty M; Department of Surgery, Mayo Clinic, Rochester, MN (Mark Truty, Rory Smoot)., Smoot R; Department of Surgery, Mayo Clinic, Rochester, MN (Mark Truty, Rory Smoot)., Bekaii-Saab T; Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ, USA (Pedro Luiz Serrano Uson Junior, Tanios Bekaii-Saab, Mitesh J. Boarad)., Stucky CC; Department of Surgery, Mayo Clinic, Phoenix, AZ, USA (Chee-Chee Stucky)., Babiker H; Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA (Hani Babiker)., Borad MJ; Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ, USA (Pedro Luiz Serrano Uson Junior, Tanios Bekaii-Saab, Mitesh J. Boarad).; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA (Mitesh J. Borad).; Mayo Clinic Cancer Center, 5777 E Mayo Blvd, Phoenix, AZ, USA (Mitesh J. Borad).
Jazyk:	angličtina
Zdroj:	Annals of gastroenterology [Ann Gastroenterol] 2024 Jan-Feb; Vol. 37 (1), pp. 95-103. Date of Electronic Publication: 2023 Dec 20.
DOI:	10.20524/aog.2024.0845
Abstrakt:	Background: Cholangiocarcinoma is an epithelial malignancy of the intrahepatic or extrahepatic biliary tree, primarily driven by chronic inflammation and fibrosis. Fibrosis has been shown to correlate with malignancy, and the aminotransferase-platelet ratio index (APRI) score, a marker for hepatic fibrosis, has proved useful in prognosticating hepatocellular carcinoma. This study aimed to assess the utility of APRI score in predicting post-surgical outcomes in cholangiocarcinoma patients. Methods: Clinical data from a total of 152 cholangiocarcinoma patients who underwent surgical resection at the Mayo Clinic were collected. The data were subsequently analyzed to determine if there was a relationship between APRI score and the demographic, laboratory, pathologic and outcome data, including overall survival. To determine the relationship between quantitative and qualitative data and the APRI score, a P-value <0.05 was considered as statistically significant. Results: No relationship between APRI score and demographic factors was identified. There were correlations between APRI score and alanine transaminase, albumin and bilirubin, but the remaining laboratory parameters showed no correlation. APRI score did not prove to be useful as a prognostic tool, as it did not correlate with tumor pathology features (tumor grade t -test P=0.86, N stage ANOVA P=0.94, vascular invasion t -test P=0.59, and perineural invasion t -test P=0.14), or with post-surgical recurrence ( t -test P=0.22) and mortality ( t -test P=0.39). Conclusion: APRI score is not a prognostic tool for post-surgical outcomes in patients with cholangiocarcinoma. Competing Interests: Conflict of Interest: None (Copyright: © Hellenic Society of Gastroenterology.)
Databáze:	MEDLINE
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