Heparin Binding Protein in Early Differential Diagnosis of Bacterial Meningitis.

Autor: Namiduru ES; Faculty of Health Sciences, Department of Nutrition and Dietetics, University of Gaziantep, Gaziantep, Turkey., Namiduru M; Faculty of Medicine, Department of Infectious Disease, University of Gaziantep, Gaziantep, Turkey., Karaoğlan İ; Faculty of Medicine, Department of Infectious Disease, University of Gaziantep, Gaziantep, Turkey., Erbağci E; Faculty of Medicine, Department of Infectious Disease, University of Gaziantep, Gaziantep, Turkey.
Jazyk: angličtina
Zdroj: Indian journal of clinical biochemistry : IJCB [Indian J Clin Biochem] 2024 Jan; Vol. 39 (1), pp. 118-123. Date of Electronic Publication: 2022 Aug 09.
DOI: 10.1007/s12291-022-01066-4
Abstrakt: Heparin-binding protein is a serine protease that is mobilized rapidly from emigrating polymorphonuclear leukocytes that acts as a chemoattractant activator of monocyte and macrophages. We investigated the potential role and efficacy of serum and cerebrospinal fluid heparin binding protein in differentiating bacterial meningitis from tuberculosis and viral meningitis. A case diagnosed with acute bacterial meningitis (n:37), viral meningitis (n:30) and tuberculous meningitis (n:30) was included in this study. The diagnosis was based on history, clinical criteria, cerebrospinal fluid examination, latex agglutination and culture, and response to therapy. Heparin-binding protein was measured using enzyme-linked immunosorbent technique in both cerebrospinal fluid and serum. Cerebrospinal fluid heparin-binding protein levels were 7.81 ± 0.23 ng/mL in bacterial meningitis, 6.11 ± 0.3 ng/mL in tuberculosis meningitis and 5.75 ± 0.1 ng/mL in viral meningitis. The mean serum level was 14.98 ± 1.1 ng/mL in bacterial meningitis, 6.89 ± 0.4 ng/mL in tuberculosis meningitis, and 6.02 ± 0.4 ng/mL in viral meningitis. Both heparin-binding protein levels were significantly higher in patients with bacterial meningitis. We found that serum and cerebrospinal fluid heparin binding protein is a useful marker for differentiating bacterial meningitis from non-bacterial meningitis.
Competing Interests: Conflict of interestThe authors declare no conflicts of interest.
(© The Author(s), under exclusive licence to Association of Clinical Biochemists of India 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
Externí odkaz: