α-Glucosidase Inhibitory Activity and Cytotoxicity of CeO 2 Nanoparticles Fabricated Using a Mixture of Different Cerium Precursors.

Autor:	Matussin SN; Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam., Khan F; Institute of Fisheries Sciences, Pukyong National University, Busan 48513, Republic of Korea.; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea., Chandika P; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea., Harunsani MH; Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam., Ahmad N; Institute for Biodiversity and Environmental Research, Universiti Brunei Darussalam, Gadong, BE 1410, Brunei Darussalam.; Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE 1410, Brunei Darussalam., Kim YM; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea.; Department of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea., Jung WK; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan 48513, Republic of Korea.; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea.; Major of Biomedical Engineering, Division of Smart Healthcare and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Republic of Korea., Khan MM; Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2023 Dec 20; Vol. 9 (1), pp. 157-165. Date of Electronic Publication: 2023 Dec 20 (Print Publication: 2024).
DOI:	10.1021/acsomega.3c02524
Abstrakt:	A mixture of three distinct cerium precursors (Ce(NO 3 ) 3 ·6H 2 O, CeCl 3 ·7H 2 O, and Ce(CH 3 COO) 3 ·H 2 O) was used to prepare cerium oxide nanoparticles (CeO 2 NPs) in a polyol-mediated synthesis. Different ratios of diethylene glycol (DEG) and H 2 O were utilized in the synthesis. The properties of the synthesized CeO 2 NPs, such as structural and morphological properties, were investigated to observe the effect of the mixed cerium precursors. Crystallite sizes of 7-8 nm were obtained for all samples, and all synthesized samples were confirmed to be in the cubic phase. The average particle sizes of the spherical CeO 2 were between 9 and 13 nm. The successful synthesis of CeO 2 can also be confirmed via the vibrational band of Ce-O from the FTIR. Antidiabetic properties of the synthesized CeO 2 NPs were investigated using α-glucosidase enzyme inhibition assay, and the concentration of the synthesized CeO 2 NPs was varied in the study. The biocompatibility properties of the synthesized CeO 2 NPs were investigated via cytotoxicity tests, and it was found that all synthesized materials showed no cytotoxic properties at lower concentrations (62.5-125 μg/mL). Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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