Rapid UV Photo-Cross-Linking of α-Lactalbumin Hydrogel Biomaterial To Enable Wound Healing.

Autor:	Huang Y; Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310027, China., Zhu Q; Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310027, China., Zhu Y; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China., Valencak TG; Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310027, China., Han Y; The State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China., Ren T; Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310027, China., Guo C; School of Engineering, Westlake University, Hangzhou, Zhejiang 310023, China., Ren D; Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310027, China.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2023 Dec 29; Vol. 9 (1), pp. 401-412. Date of Electronic Publication: 2023 Dec 29 (Print Publication: 2024).
DOI:	10.1021/acsomega.3c05793
Abstrakt:	Although both the function and biocompatibility of protein-based biomaterials are better than those of synthetic materials, their usage as medical material is currently limited by their high costs, low yield, and low batch-to-batch reproducibility. In this article, we show how α-lactalbumin (α-LA), rich in tryptophan, was used to produce a novel type of naturally occurring, protein-based biomaterial suitable for wound dressing. To create a photo-cross-linkable polymer, α-LA was methacrylated at a 100-g batch scale with >95% conversion and 90% yield. α-LAMA was further processed using photo-cross-linking-based advanced processing techniques such as microfluidics and 3D printing to create injectable hydrogels, monodispersed microspheres, and patterned scaffolds. The obtained α-LAMA hydrogels show promising biocompatibility and degradability during in vivo testing. Additionally, the α-LAMA hydrogel can accelerate post-traumatic wound healing and promote new tissue regeneration. In conclusion, cheap and safe α-LAMA-based biomaterials could be produced, and they have a beneficial effect on wound healing. As a result, there may arise a potential partnership between the dairy industry and the development of pharmaceuticals. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
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