EPRIM: An approach of identifying cancer immune-related epigenetic regulators.

Autor:	Shi A; Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, People's Republic of China.; Joint Centre of Translational Medicine, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, People's Republic of China.; Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, People's Republic of China., Lin C; Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, People's Republic of China., Wang J; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, People's Republic of China.; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Chen Y; Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, People's Republic of China., Zhong J; Wenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China., Lyu J; Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, People's Republic of China.; Joint Centre of Translational Medicine, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, People's Republic of China.; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325001, People's Republic of China.
Jazyk:	angličtina
Zdroj:	Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2023 Dec 13; Vol. 35 (1), pp. 102100. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2024).
DOI:	10.1016/j.omtn.2023.102100
Abstrakt:	Epigenetic regulation contributes to the dysregulation of gene expression involved in cancer biology. Nevertheless, the roles of epigenetic regulators (ERs) in tumor immunity and immune response remain basically unclear. Here, we developed the epigenetic regulator in immunology (EPRIM) approach to identify immune-related ERs and comprehensively dissected the ER regulation in tumor immune response across 33 cancers. The identified immune-related ERs were related to immune infiltration and could stratify cancer patients into two risk groups in multiple independent datasets. These patient groups were characterized by distinct immune functions, immune infiltrates, driver gene mutations, and prognoses. Furthermore, we constructed an immune ER-based signature and highlighted its potential utility in predicting clinical benefit from immunotherapy and selecting therapeutic agents. Taken together, our identification and evaluation of immune-related ERs highlight the usefulness of EPRIM for the understanding of ERs in immune regulation and the clinical relevance in evaluation of cancer patient prognosis and response to immune checkpoint blockade therapy. Competing Interests: The authors declare no competing interests. (© 2023 The Author(s).)
Databáze:	MEDLINE
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