The role of microorganisms in the biotransformation of psychoactive substances and its forensic relevance: a critical interdisciplinary review.
| Autor: | de Campos EG; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.; Department of Chemistry and Fermentation Sciences, Appalachian State University, Boone, NC, USA., de Almeida OGG; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., De Martinis ECP; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Forensic sciences research [Forensic Sci Res] 2023 Sep 04; Vol. 8 (3), pp. 173-184. Date of Electronic Publication: 2023 Sep 04 (Print Publication: 2023). |
| DOI: | 10.1093/fsr/owad025 |
| Abstrakt: | Microorganisms are widespread on the planet being able to adapt, persist, and grow in diverse environments, either rich in nutrient sources or under harsh conditions. The comprehension of the interaction between microorganisms and drugs is relevant for forensic toxicology and forensic chemistry, elucidating potential pathways of microbial metabolism and their implications. Considering the described scenario, this paper aims to provide a comprehensive and critical review of the state of the art of interactions amongst microorganisms and common drugs of abuse. Additionally, other drugs of forensic interest are briefly discussed. This paper outlines the importance of this area of investigation, covering the intersections between forensic microbiology, forensic chemistry, and forensic toxicology applied to drugs of abuse, and it also highlights research potentialities. Key Points: Microorganisms are widespread on the planet and grow in a myriad of environments.Microorganisms can often be found in matrices of forensic interest.Drugs can be metabolized or produced (e.g. ethanol) by microorganisms. (© The Author(s) 2023. Published by OUP on behalf of the Academy of Forensic Science.) |
| Databáze: | MEDLINE |
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