Impact of maternal stress on metabolism and penile morphology in young offspring rats.

Autor:	Macedo C; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Monnerat J; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil., Lucchetti B; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil., Teixeira G; Federal Fluminense University, Physiology and Pharmacology Department, Niteroi, Brazil., Mentzinger J; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil., Rocha H; Federal Fluminense University, Physiology and Pharmacology Department, Niteroi, Brazil., Medeiros R; Federal Fluminense University, Exercise Science Laboratory (LACE), Niteroi, Brazil., Rocha N; Federal Fluminense University, Physiology and Pharmacology Department, Niteroi, Brazil., de Souza D; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Sampaio F; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil., Gregorio B; Urogenital Research Unit, Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, Brazil. biancamgregorio.uerj@gmail.com.
Jazyk:	angličtina
Zdroj:	Histology and histopathology [Histol Histopathol] 2024 Aug; Vol. 39 (8), pp. 1009-1015. Date of Electronic Publication: 2023 Dec 27.
DOI:	10.14670/HH-18-698
Abstrakt:	Exposure to prolonged stress in pregnancy and/or lactation can lead to the future development of diseases. We aimed to study the effects of maternal stress on the biometry, metabolism, and penile morphology of young Wistar rats. Animals were divided into two experimental groups: Control Group (C) - pups from control mothers, without any intervention (n=5); and Chronic Stress Group (S) - pups from mothers who suffered variable stress in the third week of pregnancy (14th to 21st day; n=5). Food intake and body mass of the pups (n=10, in the C group and n=9 in the S group) were checked; at euthanasia (three months old), fat deposits and penis were removed. At birth and weaning, S animals were lighter than C animals, [-33.72% ( p =0.0422) and -17.07% ( p =0.0018)], respectively. However, the final body mass and body mass delta showed no differences. Food intake and fat deposits also did not differ. However, the S group was hyperglycemic at 30 and 60 days of life [+20.59% ( p =0.0042) and +14.56% ( p =0.0079), respectively], despite the glycemia measured at 90 days showing no difference between groups. Penile areas and surface densities of the corpora cavernosa components were similar between groups. The results indicate that maternal stress is an important metabolic programmer, which generates low birth weight and accelerated recovery of body mass after birth (catch-up). However, in an early analysis (90 days of life), exposure to gestational stress did not change the morphology of the offspring's penis in adulthood. (©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License.)
Databáze:	MEDLINE
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