Effects of polyphenol in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

Autor: Almeida Balieiro CC; Amazonas State University, Division of Medicine, Brazil. Electronic address: carolinecbalieiro@gmail.com., Hespanhol LC; Federal University of Campina Grande, Division of Medicine, Brazil., Mendes Fonseca L; Faculty of Medical Sciences of Minas Gerais, Division of Medicine, Brazil., Wantowski S; Joinville Region University, Division of Medicine, Brazil., Freitas MAA; State University of Região Tocantina do Maranhão, Division of Medicine, Brazil., Dias YJM; Washington University in St Louis, Division of Medicine, USA., Burlá MM; Estácio de Sá Vista Carioca University, Division of Medicine, Brazil., Maria Lima de Oliveira L; Harvard T.H Chan School of Public Health - Principles and Practice of Clinical Research (PPCR) - Post-graduate Program, ECPE, Boston, MA, USA.
Jazyk: angličtina
Zdroj: European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2024 Mar; Vol. 294, pp. 84-91. Date of Electronic Publication: 2023 Dec 30.
DOI: 10.1016/j.ejogrb.2023.12.038
Abstrakt: Objective: Polycystic ovary syndrome (PCOS) is an endocrinopathy with a high prevalence in women of reproductive age. Different treatments were tested to increase insulin sensitivity and hormone regulation, and recently polyphenols have emerged as a promising option for these women. We aimed to perform a systematic review and meta-analysis of randomized clinical trials (RCTs) comparing polyphenols to placebo in PCOS.
Design: A systematic review and meta-analysis.
Methods: PubMed, Cochrane Library, and Embase databases were searched for RCTs comparing polyphenols to placebo. Random-effects model was used to calculate the Mean Difference (MD) and Standardized Mean Difference (SMD), with 95% confidence interval (CIs).
Results: A total of fifteen RCTs comprising 916 patients were included, of whom 445 (49 %) received polyphenols. Compared to placebo, polyphenols significantly reduced serum insulin level (MD -2.49; 95 % CI [-3.72, -1.25]; p < 0.01), BMI levels (MD -0.12; 95 % CI [-0.18, -0.06]; p < 0.01), and LH levels (MD -0.87; 95 % CI [-1.54, -0.20]; p = 0.01). There was no significant difference between groups in testosterone levels (SMD -0.14; 95 % CI [-0.53, 0.25]; p = 0.48).
Conclusion: In this meta-analysis polyphenols were associated with a reduction in serum insulin, LH levels, and BMI in women with PCOS, compared to placebo. These findings support the effectiveness of polyphenols in women with PCOS.
Significant Statement: There are no comprehensive systematic recommendations for polyphenols in PCOS treatment. However, increasing evidence has highlighted its substantial impact on women's health. This systematic review and meta-analysis provide evidence for the efficacy of polyphenols in reducing serum insulin, LH, and BMI in women with PCOS compared with placebo.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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