Membrane fusion and fission during eukaryogenesis.

Autor: Romero H; Laboratorio de Genómica Evolutiva, Facultad de Ciencias/CURE, Universidad de la República, Uruguay; Centro Interdisciplinario de Ciencia de Datos y Aprendizaje Automático (CICADA), Espacio Interdisciplinario, Universidad de la República, Uruguay. Electronic address: eletor@fcien.edu.uy., Aguilar PS; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Buenos Aires, Argentina. Electronic address: paguilar@iib.unsam.edu.ar., Graña M; Unidad de Bioinformática, Institut Pasteur de Montevideo, Montevideo, Uruguay., Langleib M; Laboratorio de Genómica Evolutiva, Facultad de Ciencias/CURE, Universidad de la República, Uruguay; Unidad de Bioinformática, Institut Pasteur de Montevideo, Montevideo, Uruguay., Gudiño V; Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Buenos Aires, Argentina., Podbilewicz B; Department of Biology, Technion Israel Institute of Technology, Haifa, Israel; Instituto de Fisiología Celular, UNAM, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2024 Feb; Vol. 86, pp. 102321. Date of Electronic Publication: 2024 Jan 14.
DOI: 10.1016/j.ceb.2023.102321
Abstrakt: All eukaryotes can be traced back to a single shared ancestral lineage that emerged from interactions between different prokaryotic cells. Current models of eukaryogenesis describe various selective forces and evolutionary mechanisms that contributed to the formation of eukaryotic cells. Central to this process were significant changes in cellular structure, resulting in the configuration of a new cell type characterized by internal membrane compartments. Additionally, eukaryogenesis results in a life cycle that relies on cell-cell fusion. We discuss the potential roles of proteins involved in remodeling cellular membranes, highlighting two critical stages in the evolution of eukaryotes: the internalization of symbiotic partners and a scenario wherein the emergence of sexual reproduction is linked to a polyploid ancestor generated by cell-cell fusion.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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