Evaluation of photobiomodulation therapy (PBMT) on salivary flow and composition in head and neck cancer patients undergoing radiation therapy.

Autor: Schepanski N; Department of Stomatology, Federal University of Paraná, Curitiba, PR, Brazil., Costa FS; Department of Chemistry, Federal University of Paraná, Curitiba, PR, Brazil., Machado EFM; Department of Stomatology, Federal University of Paraná, Curitiba, PR, Brazil., Pacheco MN; Department of Stomatology, Federal University of Paraná, Curitiba, PR, Brazil., Amaral CDB; Department of Chemistry, Federal University of Paraná, Curitiba, PR, Brazil., Machado RC; Embrapa Instrumentation, São Carlos, SP, Brazil., Nogueira ARA; Embrapa Pecuária Sudeste, São Carlos, SP, Brazil., Brancher JA; Pontifícia Universidade Católica do Paraná, Escola de Ciências da Vida, Curitiba, PR, Brazil., Sassi LM; Erasto Gaertner Hospital, Curitiba, PR, Brazil., de Araujo MR; Department of Stomatology, Federal University of Paraná, Curitiba, PR, Brazil. Electronic address: melissararaujo@hotmail.com.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2024 Mar; Vol. 137 (3), pp. 253-263. Date of Electronic Publication: 2023 Nov 23.
DOI: 10.1016/j.oooo.2023.11.007
Abstrakt: Objective: Assess the impact of photobiomodulation therapy (PBMT) on xerostomia, salivary flow rate (SFR) and composition in patients undergoing radiotherapy (RT) for head and neck cancer (HNC).
Study Design: Thirty patients undergoing RT (65 Gy) for HNC were enrolled. Saliva and xerostomia evaluations collected pre- and post-PBMT-RT. PBMT involved irradiation of extra and intraoral points, 15-20 sessions, 2-3 times/week. SFR, trace elements, total protein, alkaline phosphatase, xerostomia, and pH were analyzed.
Results: The average age was 60.7 years. After treatment, there was not a significant reduction in SFR and there was no difference on xerostomia. Significant reductions in Al, Cd, Fe, Ni, P, and Sb concentrations were observed, along with a significant increase in Mg concentration. Sample data were organized into 3 groups based on a self-organizing map. Low concentrations of Al, As, Co, Cr, Cu, Fe, Mn, Mo, S, Sr, and Zn were the primary discriminatory factors for group A, while group B consisted of post-PBMT-RT samples with high concentrations of Ca, K, Mg, Na, and S.
Conclusions: PBMT prevented a significant reduction in SFR and xerostomia induced by radiation therapy. These findings suggest that PBMT prevents salivary gland damage minimizing the decline in salivary flow.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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