Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity.

Autor:	Melum VJ; Arctic seasonal timekeeping initiative (ASTI), UiT-The Arctic University of Norway, Department of Arctic and Marine Biology, Arctic Chronobiology and Physiology Research Group, NO-9037 Tromsø, Norway; University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg 67000, France., Sáenz de Miera C; University of Michigan Medical School, Department of Molecular and Integrative Physiology, Ann Arbor, MI 48109, USA., Markussen FAF; Arctic seasonal timekeeping initiative (ASTI), UiT-The Arctic University of Norway, Department of Arctic and Marine Biology, Arctic Chronobiology and Physiology Research Group, NO-9037 Tromsø, Norway., Cázarez-Márquez F; Arctic seasonal timekeeping initiative (ASTI), UiT-The Arctic University of Norway, Department of Arctic and Marine Biology, Arctic Chronobiology and Physiology Research Group, NO-9037 Tromsø, Norway., Jaeger C; University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg 67000, France., Sandve SR; Faculty of Biosciences, Norwegian University of Life Sciences (NMBU), NO-1432 Ås, Norway., Simonneaux V; University of Strasbourg, Institute of Cellular and Integrative Neurosciences, Strasbourg 67000, France., Hazlerigg DG; Arctic seasonal timekeeping initiative (ASTI), UiT-The Arctic University of Norway, Department of Arctic and Marine Biology, Arctic Chronobiology and Physiology Research Group, NO-9037 Tromsø, Norway. Electronic address: david.hazlerigg@uit.no., Wood SH; Arctic seasonal timekeeping initiative (ASTI), UiT-The Arctic University of Norway, Department of Arctic and Marine Biology, Arctic Chronobiology and Physiology Research Group, NO-9037 Tromsø, Norway. Electronic address: shona.wood@uit.no.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2024 Feb 05; Vol. 34 (3), pp. 632-640.e6. Date of Electronic Publication: 2024 Jan 12.
DOI:	10.1016/j.cub.2023.12.042
Abstrakt:	In mammals, maternal photoperiodic programming (MPP) provides a means whereby juvenile development can be matched to forthcoming seasonal environmental conditions. ¹ ^, ² ^, ³ ^, ⁴ This phenomenon is driven by in utero effects of maternal melatonin ⁵ ^, ⁶ ^, ⁷ on the production of thyrotropin (TSH) in the fetal pars tuberalis (PT) and consequent TSH receptor-mediated effects on tanycytes lining the 3 ^rd ventricle of the mediobasal hypothalamus (MBH). ⁸ ^, ⁹ ^, ¹⁰ Here we use LASER capture microdissection and transcriptomic profiling to show that TSH-dependent MPP controls the attributes of the ependymal region of the MBH in juvenile animals. In Siberian hamster pups gestated and raised on a long photoperiod (LP) and thereby committed to a fast trajectory for growth and reproductive maturation, the ependymal region is enriched for tanycytes bearing sensory cilia and receptors implicated in metabolic sensing. Contrastingly, in pups gestated and raised on short photoperiod (SP) and therefore following an over-wintering developmental trajectory with delayed sexual maturation, the ependymal region has fewer sensory tanycytes. Post-weaning transfer of SP-gestated pups to an intermediate photoperiod (IP), which accelerates reproductive maturation, results in a pronounced shift toward a ciliated tanycytic profile and formation of tanycytic processes. We suggest that tanycytic plasticity constitutes a mechanism to tailor metabolic development for extended survival in variable overwintering environments. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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