Left-sided epileptiform activity influences language lateralization in right mesial temporal sclerosis.

Autor: de Almeida JP; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; LIM-44, Department of Radiology, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Castro BM; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; LIM-44, Department of Radiology, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Passarelli V; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Chaim KT; LIM-44, Department of Radiology, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Castro-Lima H; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.; Bahiana School of Medicine and Public Health, Salvador, Brazil., Listik C; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Jorge CL; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Valerio R; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Arantes PR; LIM-44, Department of Radiology, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Amaro E Jr; LIM-44, Department of Radiology, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Pipek LZ; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Castro LH; Department of Neurology, Epilepsy Program, Clinical Hospital, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: Epilepsia open [Epilepsia Open] 2024 Apr; Vol. 9 (2), pp. 626-634. Date of Electronic Publication: 2024 Jan 13.
DOI: 10.1002/epi4.12897
Abstrakt: Objective: To investigate the association between left epileptiform activity and language laterality indices (LI) in patients with right mesial temporal sclerosis (MTS).
Methods: Twenty-two patients with right MTS and 22 healthy subjects underwent fMRI scanning while performing a language task. LI was calculated in multiple regions of interest (ROI). Data on the presence of left epileptiform abnormalities were obtained during prolonged video-EEG monitoring.
Results: After correction for multiple comparisons, LI was reduced in the middle temporal gyrus in the left interictal epileptiform discharges (IED+) group, compared with the left IED- group (p < 0.05).
Significance: Using a responsive reading naming fMRI paradigm, right MTS patients who presented left temporal interictal epileptiform abnormalities on video-EEG showed decreased LI in the middle temporal gyrus, indicating decreased left middle temporal gyrus activation, increased right middle temporal gyrus activation or a combination of both, demonstrative of language network reorganization, specially in the MTG, in this patient population.
Plain Language Summary: This research studied 22 patients with right mesial temporal sclerosis (a specific type of epilepsy) comparing them to 22 healthy individuals. Participants were asked to perform a language task while undergoing a special brain imaging technique (fMRI). The findings showed that patients with epilepsy displayed a change in the area of the brain typically responsible for language processing. This suggests that their brains may have adapted due to their condition, altering the way language is processed.
(© 2024 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
Externí odkaz: