Anti-rheumatic potential vis-à-vis aconitine and hypaconitine content analysis in different Aconitum spp. from Sikkim Himalayas (India).

Autor: Kumar B; Pharmacognosy Division, CSIR- National Botanical Research Institute, Lucknow (U.P.), 226001, India., Misra A; Pharmacognosy Division, CSIR- National Botanical Research Institute, Lucknow (U.P.), 226001, India., Rawat P; Pharmacognosy Division, CSIR- National Botanical Research Institute, Lucknow (U.P.), 226001, India., Agnihotri P; Plant Diversity, Systematics and Herbarium Division, CSIR- National Botanical Research Institute, Lucknow (U.P.), 226001, India., Srivastava S; Pharmacognosy Division, CSIR- National Botanical Research Institute, Lucknow (U.P.), 226001, India.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Feb; Vol. 21 (2), pp. e202301656. Date of Electronic Publication: 2024 Jan 31.
DOI: 10.1002/cbdv.202301656
Abstrakt: Aconitum spp. are important medicinal plants mentioned in Ayurveda as Ativisa or Vatsanabha. The present study aims to evaluate anti-rheumatic potential in seven Aconitum species and correlation with aconitine and hypaconitine content. Anti-rheumatic potential was analyzed through in vitro xanthine oxidase inhibition, anti-inflammatory and ROS scavenging assays; and quantification of aconitine and hypaconitine with RP-HPLC method validated as per ICH guidelines. The findings reveal that A. palmatum possessed the most promising response (IC 50 =12.68±0.15 μg/ml) followed by A. ferox (IC 50 =12.912±1.87 μg/ml) for xanthin oxidase inhibition. We observed a wide variation in aconitine and hypaconitine content ranging from 0.018 %-1.37 % and 0.0051 %-0.077 % respectively on dry weight basis. Aconitine and hypaconitine showed moderate positive correlation (r=0.68 and 0.59 respectively) with anti-rheumatic potential. The study identifies potential alternative species of Aconitum that can help in sustainable availability of quality raw material.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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