Evolutionary history of the cytochrome P450s from Colletotrichum species and prediction of their putative functional roles during host-pathogen interactions.

Autor: Ortiz-Álvarez J; Institute for Agrobiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Villamayor, Salamanca, Spain.; Present Address: Programa 'Investigadoras e Investigadores por México' Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCyT), Mexico City, México., Becerra S; Institute for Agrobiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Villamayor, Salamanca, Spain., Baroncelli R; Institute for Agrobiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Villamayor, Salamanca, Spain.; Department of Agricultural and Food Sciences, University of Bologna, Bologna, Italy., Hernández-Rodríguez C; Laboratorio de Biología Molecular de Bacterias y Levaduras, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de Mexico, México., Sukno SA; Institute for Agrobiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Villamayor, Salamanca, Spain. ssukno@usal.es., Thon MR; Institute for Agrobiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Villamayor, Salamanca, Spain. mthon@usal.es.
Jazyk: angličtina
Zdroj: BMC genomics [BMC Genomics] 2024 Jan 12; Vol. 25 (1), pp. 56. Date of Electronic Publication: 2024 Jan 12.
DOI: 10.1186/s12864-023-09858-5
Abstrakt: The genomes of species belonging to the genus Colletotrichum harbor a substantial number of cytochrome P450 monooxygenases (CYPs) encoded by a broad diversity of gene families. However, the biological role of their CYP complement (CYPome) has not been elucidated. Here, we investigated the putative evolutionary scenarios that occurred during the evolution of the CYPome belonging to the Colletotrichum Graminicola species complex (s.c.) and their biological implications. The study revealed that most of the CYPome gene families belonging to the Graminicola s.c. experienced gene contractions. The reductive evolution resulted in species restricted CYPs are predominant in each CYPome of members from the Graminicola s.c., whereas only 18 families are absolutely conserved among these species. However, members of CYP families displayed a notably different phylogenetic relationship at the tertiary structure level, suggesting a putative convergent evolution scenario. Most of the CYP enzymes of the Graminicola s.c. share redundant functions in secondary metabolite biosynthesis and xenobiotic metabolism. Hence, this current work suggests that the presence of a broad CYPome in the genus Colletotrichum plays a critical role in the optimization of the colonization capability and virulence.
(© 2024. The Author(s).)
Databáze: MEDLINE
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