Erythrokinetic mechanism(s) causing the "late anemia" of hemolytic disease of the fetus and newborn.

Autor: Christensen RD; Women and Newborns Research, Intermountain Health, Murray, UT, USA. Robert.christensen@hsc.utah.edu.; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. Robert.christensen@hsc.utah.edu., Bahr TM; Women and Newborns Research, Intermountain Health, Murray, UT, USA.; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Ohls RK; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Ilstrup SJ; Transfusion Medicine, Department of Pathology, Intermountain Health, Murray, UT, USA., Moise KJ Jr; Comprehensive Fetal Care Center at Dell Children's Medical Center and Department of Women's Health, Dell Medical School, Austin, TX, USA., Lopriore E; Division of Neonatology, Leiden University Medical Centre, Leiden, Netherlands., Meznarich JA; Division of Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Jun; Vol. 44 (6), pp. 916-919. Date of Electronic Publication: 2024 Jan 12.
DOI: 10.1038/s41372-024-01872-z
Abstrakt: A transfusion-requiring "late anemia" can complicate the management of neonates convalescing from hemolytic disease of the fetus and newborn (HDFN). This anemia can occur in any neonate after HDFN but is particularly prominent in those who received intrauterine transfusions and/or double-volume exchange transfusions. Various reports describe this condition as occurring based on ongoing hemolysis, either due to passive transfer of alloantibody through breast milk or persistence of antibody not removed by exchange transfusion. However, other reports describe this condition as the result of inadequate erythrocyte production. Both hypotheses might have merit, because perhaps; (1) some cases are primarily due to continued hemolysis, (2) others are primarily hypoproductive, and (3) yet others result from a mixture of these two mechanisms. We propose prospective collaborative studies that will resolve this issue by serially quantifying end-tidal carbon monoxide. Doing this will better inform the assessment and treatment of neonates recovering from HDFN.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
Externí odkaz: