1D and 2D Coordination Polymers of Calcium with Nonsteroidal Anti-Inflammatory Drugs: Synthesis, Crystal Structures, Hirshfeld Surfaces, Antimicrobial and Antioxidant Activities.

Autor: Gacki M; Institute of General and Ecological Chemistry, Faculty of Chemistry, Łódź University of Technology, Żeromskiego 116, 90-924, Łódź, Poland., Kafarska K; Institute of General and Ecological Chemistry, Faculty of Chemistry, Łódź University of Technology, Żeromskiego 116, 90-924, Łódź, Poland., Korona-Głowniak I; Department of Pharmaceutical Microbiology, Medial University of Lublin, Chodźki 1, 20-093, Lublin, Poland., Schab P; Institute of General and Ecological Chemistry, Faculty of Chemistry, Łódź University of Technology, Żeromskiego 116, 90-924, Łódź, Poland., Wojciechowski J; Rigaku Europe SE, Hugenottenallee 167, 63263, Neu-Isenburg, Germany., Gierczak N; Institute of General and Ecological Chemistry, Faculty of Chemistry, Łódź University of Technology, Żeromskiego 116, 90-924, Łódź, Poland., Wolf WM; Institute of General and Ecological Chemistry, Faculty of Chemistry, Łódź University of Technology, Żeromskiego 116, 90-924, Łódź, Poland.
Jazyk: angličtina
Zdroj: ChemPlusChem [Chempluschem] 2024 May; Vol. 89 (5), pp. e202300734. Date of Electronic Publication: 2024 Jan 29.
DOI: 10.1002/cplu.202300734
Abstrakt: Four alkaline earth metal complexes of ketoprofen (Hket) and indomethacin (Hind) were synthesized and characterized: [Ca(ket) 2 (H 2 O) 2 ] n (1), [Mg(ket) 2 (H 2 O) 2 ] (2), [Ca(ind) 2 (EtOH) 2 ] n (3), and [Mg(ind) 2 (EtOH) 2 ] (4). All compounds were studied by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Crystal structures of 1 and 3 were determined by single crystal X-ray diffraction technique T=100 K. The structure of 1 is dominated by a one-dimensional coordination polymer, while 3 is formed by a two-dimensional layer stabilized by the calcium zig-zag chains and π⋅⋅⋅π stacking interactions. Crystal packing arrangements were characterized by fingerprint plots (FPs) that were derived from the Hirshfeld surfaces (HSs). The antioxidant and antimicrobial activities of complexes were evaluated against Gram-positive and Gram-negative bacteria as well as yeasts.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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