Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.

Autor:	Ho PC; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; The Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Yu WH; Brain Health and Imaging Center and Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada., Tee BL; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.; Global Brain Health Institute, University of California, San Francisco, San Francisco, California, USA., Lee WP; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Li C; Alzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Gu Y; Department of Neurology, Columbia University Medical Center, New York, New York, USA., Yokoyama JS; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA.; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA., Reyes-Dumeyer D; Gertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, New York, New York, USA., Choi YB; Englewood Health, Englewood, New Jersey, USA.; Department of Neurology, Rutgers New Jersey Medical School, Newark, New Jersey, USA., Yang HS; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Vardarajan BN; Gertrude H. Sergievsky Center, Taub Institute of Aging Brain and Department of Neurology at Columbia University, New York, New York, USA., Tzuang M; Department of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA., Lieu K; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA., Lu A; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA., Faber KM; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Potter ZD; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Revta C; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA., Kirsch M; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., McCallum J; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Mei D; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA., Booth B; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Cantwell LB; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chen F; Department of Neurology, Columbia University Medical Center, New York, New York, USA., Chou S; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Clark D; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Deng M; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Hong TH; University of Southern California, Los Angeles, California, USA., Hwang LJ; Stanford Alzheimer's Disease Research Center, Stanford, California, USA., Jiang L; University of Southern California, Los Angeles, California, USA., Joo Y; Department of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA., Kang Y; College of Nursing, Graduate Program in System Health Science and Engineering, Ewha Womans University, Seoul, Republic of Korea., Kim ES; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Kim H; Department of Neurology, Chosun University Hospital, Dong-gu, Gwangju, Republic of Korea., Kim K; Department of Child Development and Family Studies, College of Human Ecology, Seoul National University, Jongno-gu, Seoul, Republic of Korea., Kuzma AB; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lam E; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Lanata SC; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA., Lee K; Biomedical Science, College of Natural Sciences, Chosun University, Gwanak-gu, Seoul, Republic of Korea., Li D; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA., Li M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Li X; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Liu CL; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Liu C; Department of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA., Liu L; Alzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lupo JL; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA., Nguyen K; Department of Medicine, University of California at San Diego, La Jolla, California, USA., Pfleuger SE; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Qian J; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA., Qian W; Geriatric Mental Health Services, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Ramirez V; Stanford Alzheimer's Disease Research Center, Stanford, California, USA., Russ KA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Seo EH; Premedical Science, College of Medicine, Chosun University, Dong-gu, Gwangju, Republic of Korea., Song YE; Department of Population & Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Tian L; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, USA., Torres M; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA., Vo N; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA., Wong EC; Department of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA.; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, California, USA., Xie Y; Department of Neurology, Columbia University Medical Center, New York, New York, USA., Yau EB; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Yi I; Stanford Alzheimer's Disease Research Center, Stanford, California, USA., Yu V; Department of Ophthalmology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA., Zeng X; Alzheimer's Disease Research Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., St George-Hyslop P; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA., Au R; Department of Anatomy and Neurobiology, Slone Epidemiology Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA., Schellenberg GD; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Dage JL; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, USA., Hsiung GR; Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Rosen H; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California, USA., Henderson VW; Department of Epidemiology and Population Health, Stanford University, Stanford, California, USA.; Department of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA., Foroud T; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Kukull WA; Department of Epidemiology, University of Washington, Seattle, Washington, USA., Peavy GM; Department of Neurosciences, University of California San Diego, La Jolla, California, USA., Lee H; Rory Meyers College of Nursing, New York University, New York, New York, USA., Feldman HH; Alzheimer's Disease Cooperative Study, University of California, San Diego, La Jolla, California, USA.; Department of Neurosciences, University of California San Diego, La Jolla, California, USA., Mayeux R; Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, Vagelos College of Physicians and Surgeons, New York, New York, USA., Chui H; Department of Neurology, Keck School of Medicine at University of Southern California, Los Angeles, California, USA., Jun GR; Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Ta Park VM; Department of Community Health Systems, University of California San Francisco School of Nursing, San Francisco, California, USA.; Asian American Research Center on Health (ARCH), University of California San Francisco School of Nursing, San Francisco, California, USA., Chow TW; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Alector Inc., South San Francisco, California, USA., Wang LS; Penn Neurodegeneration Genomics Center, Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Mar; Vol. 20 (3), pp. 2058-2071. Date of Electronic Publication: 2024 Jan 12.
DOI:	10.1002/alz.13611
Abstrakt:	Introduction: Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population. Methods: The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese. Results: ACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception. Discussion: ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non-genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness. Highlights: The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under-investment in clinical research for Asians. We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease. We describe culturally appropriate recruitment strategies and data collection protocol. ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities. We aim to implement a successful recruitment program that enrolls across three Asian subcommunities. (© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze:	MEDLINE
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