Erosive Hand Osteoarthritis: Recent Advances and Future Treatments.

Autor: Bean MB; Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. marta.bean@pennmedicine.upenn.edu., Favero M; Rheumatology Unit, Department of Medicine-DIMED, Padova University Hospital, Padova, Italy.; Medicine Unit 1, Ca' Foncello Hospital, Treviso, Italy., Ramonda R; Rheumatology Unit, Department of Medicine-DIMED, Padova University Hospital, Padova, Italy., Scanzello CR; Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Department of Medicine & Translational Musculoskeletal Research Center, Corp. Crescenz VA Medical Center, Philadelphia, PA, 19104, USA.
Jazyk: angličtina
Zdroj: Current rheumatology reports [Curr Rheumatol Rep] 2024 Apr; Vol. 26 (4), pp. 103-111. Date of Electronic Publication: 2024 Jan 12.
DOI: 10.1007/s11926-023-01130-9
Abstrakt: Purpose of the Review: Erosive hand osteoarthritis (EHOA) is an aggressive form of hand osteoarthritis that leads to significant disability, and recent data suggests that it is increasing in prevalence. This review provides an update of our current understanding of epidemiology, genetic associations, biomarkers, pathogenesis, and treatment of EHOA, with particular focus on studies published within the last 5 years.
Recent Findings: New studies of EHOA have identified new genetic loci associated with disease, including variants in genes involved in inflammation and bone remodeling. Preclinical studies implicate pathways of innate immunity, including some that may be causal in the condition. Recent novel studies showed that inflammatory features identified by ultrasound and MRI are associated with development of erosive lesions over time on conventional radiography. In the future, these imaging modalities may be useful in identifying patients at risk of adverse outcomes. Promising new findings in genetics, biomarkers, and treatment targets will hopefully allow for future therapeutic options for this debilitating condition.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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