Understanding the pathogenic mechanisms and therapeutic effects in neurocysticercosis.
Autor: | Castillo G; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru., Fustamante L; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru., Delgado-Kamiche AD; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States., Camen-Orozco RP; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States., Clark T; The Department of International Health, Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Emergency Medicine, SUNY Downstate Medical Center, Kings County Hospital Medical Center, Brooklyn, New York, New York, United States., Bernal E; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru., Morales-Alvarez J; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru., Ferrufino M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Mamani-Palomino J; Facultad de Medicina Veterinaria y Salud animal, Universidad Peruana Cayetano Heredia, Lima, Peru., Bustos JA; Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru., Garcia HH; Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Gavidia CM; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Gilman RH; The Department of International Health, Bloomberg School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland, USA., Verastegui M; Infectious Diseases Laboratory Research-LID, Facultad de Ciencia e Ingeniería, Universidad Peruana Cayetano Heredia, Lima, Peru.; Asociación Benéfica Prisma, Lima, Peru. |
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Jazyk: | angličtina |
Zdroj: | Brain pathology (Zurich, Switzerland) [Brain Pathol] 2024 Sep; Vol. 34 (5), pp. e13237. Date of Electronic Publication: 2024 Jan 11. |
DOI: | 10.1111/bpa.13237 |
Abstrakt: | Despite being a leading cause of acquired seizures in endemic regions, the pathological mechanisms of neurocysticercosis are still poorly understood. This study aims to investigate the impact of anthelmintic treatment on neuropathological features in a rat model of neurocysticercosis. Rats were intracranially infected with Taenia solium oncospheres and treated with albendazole + praziquantel (ABZ), oxfendazole + praziquantel (OXF), or untreated placebo (UT) for 7 days. Following the last dose of treatment, brain tissues were evaluated at 24 h and 2 months. We performed neuropathological assessment for cyst damage, perilesional brain inflammation, presence of axonal spheroids, and spongy changes. Both treatments showed comparable efficacy in cyst damage and inflammation. The presence of spongy change correlated with spheroids counts and were not affected by anthelmintic treatment. Compared to white matter, gray matter showed greater spongy change (91.7% vs. 21.4%, p < 0.0001), higher spheroids count (45.2 vs. 0.2, p = 0.0001), and increased inflammation (72.0% vs. 21.4%, p = 0.003). In this rat model, anthelmintic treatment destroyed brain parasitic cysts at the cost of local inflammation similar to what is described in human neurocysticercosis. Axonal spheroids and spongy changes as markers of damage were topographically correlated, and not affected by anthelmintic treatment. (© 2024 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.) |
Databáze: | MEDLINE |
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