Objectively measured prolonged sleep is associated with plasma cytokines in older adults with mild cognitive impairment.

Autor: Tokunaga A; Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan., Kimura N; Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan., Masuda T; Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan., Hanaoka T; Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan., Matsubara E; Department of Neurology, Faculty of Medicine, Oita University, Yufu, Japan.
Jazyk: angličtina
Zdroj: Journal of sleep research [J Sleep Res] 2024 Oct; Vol. 33 (5), pp. e14135. Date of Electronic Publication: 2024 Jan 11.
DOI: 10.1111/jsr.14135
Abstrakt: This study aimed to determine whether objective sleep time is associated with the concentrations of various plasma cytokines in older adults with mild cognitive impairment (MCI). In total, 118 adults with MCI (66 women; mean age: 75.7 years) participated in this prospective cohort study. All participants were required to wear a wristband sensor for 7.8 days, on average, every 3 months for 1 year and undergo measurement of 27 plasma cytokines using multiplex immunoassays. After adjusting for potential confounders, the associations of total sleep time with cytokine concentrations were assessed by multiple linear regression analysis. The total sleep time was significantly correlated with plasma interleukin (IL)-9 and macrophage inflammatory protein (MIP)-1β levels (r = 0.239, p = 0.009, and r = 0.242, p = 0.008, respectively). Moreover, these associations remained significant after adjusting for covariates, including demographic characteristics, lifestyle-related diseases, and apolipoprotein E status (β = 0.272, 95% confidence interval: 0.095-0.448, p = 0.003, and β = 0.27, 95% confidence interval: 0.092-0.449, p = 0.003, respectively). Thus, this study is the first to demonstrate the association between objective prolonged sleep and higher plasma IL-9 and MIP-1β levels in older adults with MCI.
(© 2024 European Sleep Research Society.)
Databáze: MEDLINE
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