Effects of potassium sorbate on systemic inflammation and gut microbiota in normal mice: A comparison of continuous intake and washout period.

Autor: Xiao N; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China., Ruan S; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China., Mo Q; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China., Zhao M; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China., Liu T; Xianghu Laboratory, Hangzhou, 311231, China., Feng F; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; Ningbo Research Institute, Zhejiang University, Ningbo, 315100, China; ZhongYuan Institute, Zhejiang University, Zhengzhou, 450001, China. Electronic address: fengfq@zju.edu.cn.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Feb; Vol. 184, pp. 114443. Date of Electronic Publication: 2024 Jan 09.
DOI: 10.1016/j.fct.2024.114443
Abstrakt: Potassium sorbate (PS) is a widely used food preservative in the field of food industry. However, the effects of continuous intake and washout period of PS on host health are still unclear. In this study, to investigate long-term effect and after-effect of different concentrations and time points of PS, healthy mice were orally exposed to 150 mg/kg, 500 mg/kg and 1000 mg/kg of PS for 10 weeks, and washout treatment for another 5 weeks, respectively. The results indicated that PS intake for 10 weeks had no obvious effects on organs and adipose tissue, nor did it noteworthily interfere with glucolipid metabolism in the serum. However, it caused inflammatory cell infiltration in the liver, increased serum interleukin (IL)-1β level, changed abundances of gut microbiota but failed to promote the production of short chain fatty acids in the gut. After washout period for 5 weeks, liver inflammation and IL-1β level were decreased, and gut environment developed towards a healthier condition. Specifically, PS washout significantly increased abundance of Lachnospiraceae_NK4A136_group and the production of isobutyric acid. This study confirmed washout period eliminated negative effects from continuous intake of PS, which provided positive evidence for its safety.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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