A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract.

Autor: Rodrigues CM; Laboratory of Chemistry and Biomass and Biofuels, Embrapa Agronergy, Brazilian Agricultural Research Corporation, Brasília, DF, Brazil., Bento CC; School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, SP, Brazil., Moraes CB; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., Gomes C; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil; Municipal University of Sao Caetano do Sul (USCS), Campus Centro, 09521-160, Sao Caetano, SP, Brazil., Ioshino RS; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., Freitas-Junior LH; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., de Castro Spadari C; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., Ishida K; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil., Vilegas W; Institute of Biosciences, UNESP - Sao Paulo State University, Sao Vicente, SP, Brazil., Carvalho JCS; Department of Botany, Institute of Biosciences, University of São Paulo, São Paulo, SP, Brazil., Ferreira MJP; Department of Botany, Institute of Biosciences, University of São Paulo, São Paulo, SP, Brazil., Carbone V; National Research Council of Italy, Institute of Food Sciences (CNR-ISA), Avellino, Italy., Piacente S; Department of Pharmacy, University of Salerno, Via Giovanni Paolo II n. 132, I-84084 Fisciano, SA, Italy., Molina de Angelo R; School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, SP, Brazil., Honorio KM; School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, SP, Brazil., Sannomiya M; School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: miriamsan@usp.br.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Mar; Vol. 173, pp. 105820. Date of Electronic Publication: 2024 Jan 09.
DOI: 10.1016/j.fitote.2024.105820
Abstrakt: In this study, we specifically focused on the crude methanolic leaf extract of Byrsonima coccolobifolia, investigating its antifungal potential against human pathogenic fungi and its antiviral activity against COVID-19. Through the use of high-performance liquid chromatography coupled with electrospray ionization ion trap tandem mass spectrometry, direct infusion electrospray ionization ion trap tandem mass spectrometry, and chromatographic dereplication procedures, we identified galloyl quinic acid derivatives, catechin derivatives, proanthocyanidins, and flavonoid glycosides. The broth dilution assay revealed that the methanolic leaf extract of B. coccolobifolia exhibits antifungal activity against Cryptococcus neoformans (IC 50  = 4 μg/mL). Additionally, docking studies were conducted to elucidate the interactions between the identified compounds and the central residues at the binding site of biological targets associated with COVID-19. Furthermore, the extract demonstrated an in vitro half-maximum effective concentration (EC 50  = 7 μg/mL) and exhibited significant selectivity (>90%) toward SARS-CoV-2.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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