First in-human evaluation of [1- 13 C]pyruvate in D 2 O for hyperpolarized MRI of the brain: A safety and feasibility study.
Autor: | Deh K; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Zhang G; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Park AH; Radiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA., Cunningham CH; Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Bragagnolo ND; Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada., Lyashchenko S; Radiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA., Ahmmed S; Radiochemistry & Imaging Probes Core (RMIP), Memorial Sloan Kettering Cancer Center, New York, New York, USA., Leftin A; General Electric Healthcare, New York, New York, USA., Coffee E; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Hricak H; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Miloushev V; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Mayerhoefer M; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Keshari KR; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA. |
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Jazyk: | angličtina |
Zdroj: | Magnetic resonance in medicine [Magn Reson Med] 2024 Jun; Vol. 91 (6), pp. 2559-2567. Date of Electronic Publication: 2024 Jan 11. |
DOI: | 10.1002/mrm.30002 |
Abstrakt: | Purpose: To investigate the safety and value of hyperpolarized (HP) MRI of [1- 13 C]pyruvate in healthy volunteers using deuterium oxide (D Methods: Healthy volunteers (n = 5), were injected with HP [1- 13 C]pyruvate dissolved in D Results: All volunteers completed the study safely and reported no adverse effects. The use of D Conclusions: HP [1- 13 C]pyruvate in D (© 2024 International Society for Magnetic Resonance in Medicine.) |
Databáze: | MEDLINE |
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