Identification of three unexpected new psychoactive substances at an Australian drug checking service.

Autor: Algar JL; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.; CanTEST Health and Drug Checking Service, Canberra, Australian Capital Territory, Australia., Lawes DJ; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia., Carroll AJ; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia., Caldicott D; Emergency Department, Calvary Public Hospital, Canberra, Australian Capital Territory, Australia.; ANU Medical School, Australian National University, Canberra, Australian Capital Territory, Australia., McLeod MD; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Jazyk: angličtina
Zdroj: Drug testing and analysis [Drug Test Anal] 2024 Oct; Vol. 16 (10), pp. 1144-1154. Date of Electronic Publication: 2024 Jan 11.
DOI: 10.1002/dta.3637
Abstrakt: Drug checking is a harm reduction measure that provides people with the opportunity to confirm the identity and purity of substances before consumption. The CanTEST Health and Drug Checking Service is Australia's first fixed-site drug checking service, where clients can learn about the contents of the samples they provide while receiving tailored harm reduction and health advice. Three samples were recently presented to the service with the expectation of 4-fluoromethylphenidate (4F-MPH) 1, methoxetamine (MXE) 2 and 3-methylmethcathinone (3-MMC) 3. The identity of all three samples did not meet these expectations and remained unknown on-site, as no high confidence identifications were obtained. However, further analysis by nuclear magnetic resonance spectroscopy, high resolution gas chromatography-electron ionisation-mass spectrometry and liquid chromatography-electrospray ionisation-mass spectrometry at the nearby Australian National University allowed for the structure elucidation of the three samples as 4-fluoro-α-pyrrolidinoisohexanophenone (4F-α-PiHP) 4, 1-(4-fluorobenzyl)-4-methylpiperazine (4F-MBZP) 5 and N-propyl-1,2-diphenylethylamine (propylphenidine) 6, respectively. Given all three samples were not of the expected identity and have not yet been described as new psychoactive substances in the literature, this study presents a full characterisation of each compound. As exemplified by this rapid identification of three unexpected new psychoactive substances, drug checking can be used as an effective method to monitor the unregulated drug market.
(© 2024 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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