Comprehensive Analysis of Current Treatment Approaches for Keloids in Pediatrics: A Systematic Review.

Autor:	Al Zahrani RA; Medicine and Surgery, Umm Al Qura University, Makkah, SAU., Alotaibi WN; Pediatrics, Armed Forces Hospital Southern Region, Khamis Mashait, SAU., Almanasef ZM; College of Medicine, Royal College of Surgeons in Ireland, Dublin, IRL., Malawi I; Dermatology, King Fahad General Hospital, Makkah, SAU., Mohammed LA; College of Medicine, King Khaled University, Abha, SAU., Algahamdi RA; College of Medicine, Al Bahah University, Al Bahah, SAU., Almohanna AA; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., AlKhaytan AN; College of Medicine, Qassim University, Buraydah, SAU., Albishi RJ; College of Medicine, King Abdulaziz University, Jeddah, SAU., Alsofyani YA; College of Medicine, Taif University, Taif, SAU., Aljindan FK; Plastic Surgery, King Abdullah Medical City, Makkah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Dec 10; Vol. 15 (12), pp. e50290. Date of Electronic Publication: 2023 Dec 10 (Print Publication: 2023).
DOI:	10.7759/cureus.50290
Abstrakt:	Keloids, benign fibrous growths resulting from atypical skin responses to injuries, present a complex challenge in dermatology. These lesions, characterized by excessive collagen production, often lead to physical discomfort and psychological distress. While various treatment methods exist, the lack of a universally effective modality underscores the need for a systematic evaluation of current approaches. This systematic review aims to comprehensively analyze the current available treatment modalities used for the management of keloids in the pediatric population in terms of their effectiveness, safety, and quality of life outcomes. The review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted on PubMed and Google Scholar databases to identify relevant studies published in English. The review specifically focused on randomized controlled trials involving patients under 18 diagnosed with keloids, assessing different treatment modalities, and reporting validated measures of treatment efficacy, safety outcomes, and quality of life. The risk of bias was assessed using Cochrane's Risk of Bias Tool for randomized studies to ensure the methodological quality of the included trials. Four studies met the inclusion criteria, collectively involving 196 pediatric patients. Treatment interventions included glucocorticosteroid and fusidic acid cream with silicone gel patches, botulinum toxin type A injections, and Scarban silicone gel sheets. Patient-reported outcomes exhibited varying degrees of improvement in scar size, vascularity, and pliability. Complications, such as rash and wound infection, were reported in some cases. Based on our review of the selected studies and due to the incompletely understood pathogenesis of keloids, there is an ongoing lack of universally effective treatment modality for the management of keloids resulting in their persistently high recurrence rate. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Al Zahrani et al.)
Databáze:	MEDLINE
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