Corneal Epithelial Thickness Mapping: A Major Review.

Autor: Abtahi MA; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Beheshtnejad AH; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Latifi G; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Akbari-Kamrani M; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ghafarian S; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Masoomi A; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Sonbolastan SA; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Jahanbani-Ardakani H; Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Atighechian M; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Banan L; Sunshine Coast University Hospital, Brisbane, Queensland, Australia., Nouri H; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Abtahi SH; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Journal of ophthalmology [J Ophthalmol] 2024 Jan 02; Vol. 2024, pp. 6674747. Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
DOI: 10.1155/2024/6674747
Abstrakt: The corneal epithelium (CE) is the outermost layer of the cornea with constant turnover, relative stability, remarkable plasticity, and compensatory properties to mask alterations in the underlying stroma. The advent of quantitative imaging modalities capable of producing epithelial thickness mapping (ETM) has made it possible to characterize better the different patterns of epithelial remodeling. In this comprehensive synthesis, we reviewed all available data on ETM with different methods, including very high-frequency ultrasound (VHF-US) and spectral-domain optical coherence tomography (SD-OCT) in normal individuals, corneal or systemic diseases, and corneal surgical scenarios. We excluded OCT studies that manually measured the corneal epithelial thickness (CET) (e.g., by digital calipers) or the CE (e.g., by confocal scanning or handheld pachymeters). A comparison of different CET measuring technologies and devices capable of producing thickness maps is provided. Normative data on CET and the possible effects of gender, aging, diurnal changes, refraction, and intraocular pressure are discussed. We also reviewed ETM data in several corneal disorders, including keratoconus, corneal dystrophies, recurrent epithelial erosion, herpes keratitis, keratoplasty, bullous keratopathy, carcinoma in situ, pterygium, and limbal stem cell deficiency. The available data on the potential role of ETM in indicating refractive surgeries, planning the procedure, and assessing postoperative changes are reviewed. Alterations in ETM in systemic and ocular conditions such as eyelid abnormalities and dry eye disease and the effects of contact lenses, topical medications, and cataract surgery on the ETM profile are discussed.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2024 Mohammad-Ali Abtahi et al.)
Databáze: MEDLINE
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