On the possibility of engineering social evolution in microfluidic environments.
| Autor: | Uppal G; Harvard Medical School, Boston, Massachusetts; Division of Computational Pathology, Brigham and Women's hospital, Boston, Massachusetts., Vural DC; Department of Physics, University of Notre Dame, Notre Dame, Indiana. Electronic address: dvural@nd.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Biophysical journal [Biophys J] 2024 Feb 06; Vol. 123 (3), pp. 407-419. Date of Electronic Publication: 2024 Jan 09. |
| DOI: | 10.1016/j.bpj.2024.01.007 |
| Abstrakt: | Many species of microbes cooperate by producing public goods from which they collectively benefit. However, these populations are under the risk of being taken over by cheating mutants that do not contribute to the pool of public goods. Here we present theoretical findings that address how the social evolution of microbes can be manipulated by external perturbations to inhibit or promote the fixation of cheaters. To control social evolution, we determine the effects of fluid-dynamical properties such as flow rate or domain geometry. We also study the social evolutionary consequences of introducing beneficial or harmful chemicals at steady state and in a time-dependent fashion. We show that by modulating the flow rate and by applying pulsed chemical signals, we can modulate the spatial structure and dynamics of the population in a way that can select for more or less cooperative microbial populations. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Biophysical Society. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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