Molecular Mechanisms of Neuroprotection by Ketone Bodies and Ketogenic Diet in Cerebral Ischemia and Neurodegenerative Diseases.

Autor: Jang J; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Kim SR; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Lee JE; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Lee S; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Son HJ; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea., Choe W; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Yoon KS; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Kim SS; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Yeo EJ; Department of Biochemistry, College of Medicine, Gachon University, Incheon 21999, Republic of Korea., Kang I; Department of Biomedical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.; Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 21; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 21.
DOI: 10.3390/ijms25010124
Abstrakt: Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve as crucial alternative energy sources during glucose deficiency. KBs, generated through ketogenesis in the liver, are metabolized into acetyl-CoA in extrahepatic tissues, entering the tricarboxylic acid cycle and electron transport chain for ATP production. Reduced glucose metabolism and mitochondrial dysfunction correlate with increased neuronal death and brain damage during cerebral ischemia and neurodegeneration. Both KBs and the ketogenic diet (KD) demonstrate neuroprotective effects by orchestrating various cellular processes through metabolic and signaling functions. They enhance mitochondrial function, mitigate oxidative stress and apoptosis, and regulate epigenetic and post-translational modifications of histones and non-histone proteins. Additionally, KBs and KD contribute to reducing neuroinflammation and modulating autophagy, neurotransmission systems, and gut microbiome. This review aims to explore the current understanding of the molecular mechanisms underpinning the neuroprotective effects of KBs and KD against brain damage in cerebral ischemia and neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje