Reconstructive Methodology in the Synthesis of 2-Aminopurine.

Autor: Neymash AO; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia., Ulomsky EN; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia., Fedotov VV; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia., Aminov SV; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia., Lyapustin DN; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia., Gorbunov EB; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Science, Sofii Kovalevskoy St. 22, 620137 Yekaterinburg, Russia., Ishimnikov VA; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia., Slepukhin PA; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Science, Sofii Kovalevskoy St. 22, 620137 Yekaterinburg, Russia., Rusinov VL; Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2023 Dec 25; Vol. 29 (1). Date of Electronic Publication: 2023 Dec 25.
DOI: 10.3390/molecules29010134
Abstrakt: A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of the creation of a condensed polyazotic heterocyclic tetrazolopyrimidine structure, its transformation into triaminopyrimidine, and its subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics, and the structure of the intermediate compound 5 was established directly by X-ray diffraction analysis.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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