Neuronal Autophagy: Regulations and Implications in Health and Disease.

Autor: Liénard C; NeuroMyoGene Institute-PGNM, CNRS UMR 5261-INSERM U1315, University of Claude Bernard Lyon 1, 69008 Lyon, France.; CHU Montpellier, University of Montpellier, 34295 Montpellier, France., Pintart A; NeuroMyoGene Institute-PGNM, CNRS UMR 5261-INSERM U1315, University of Claude Bernard Lyon 1, 69008 Lyon, France., Bomont P; NeuroMyoGene Institute-PGNM, CNRS UMR 5261-INSERM U1315, University of Claude Bernard Lyon 1, 69008 Lyon, France.
Jazyk: angličtina
Zdroj: Cells [Cells] 2024 Jan 04; Vol. 13 (1). Date of Electronic Publication: 2024 Jan 04.
DOI: 10.3390/cells13010103
Abstrakt: Autophagy is a major degradative pathway that plays a key role in sustaining cell homeostasis, integrity, and physiological functions. Macroautophagy, which ensures the clearance of cytoplasmic components engulfed in a double-membrane autophagosome that fuses with lysosomes, is orchestrated by a complex cascade of events. Autophagy has a particularly strong impact on the nervous system, and mutations in core components cause numerous neurological diseases. We first review the regulation of autophagy, from autophagosome biogenesis to lysosomal degradation and associated neurodevelopmental/neurodegenerative disorders. We then describe how this process is specifically regulated in the axon and in the somatodendritic compartment and how it is altered in diseases. In particular, we present the neuronal specificities of autophagy, with the spatial control of autophagosome biogenesis, the close relationship of maturation with axonal transport, and the regulation by synaptic activity. Finally, we discuss the physiological functions of autophagy in the nervous system, during development and in adulthood.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje