Progress in research on the biosynthesis of 1,2,4-butanetriol by engineered microbes.

Autor: Ma X; CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Sun C; CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.; Shandong Energy Institute, Qingdao, 266101, China.; Qingdao New Energy Shandong Laboratory, Qingdao, 266101, China., Xian M; CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China.; Shandong Energy Institute, Qingdao, 266101, China.; Qingdao New Energy Shandong Laboratory, Qingdao, 266101, China., Guo J; CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China. guojing@qibebt.ac.cn.; Shandong Energy Institute, Qingdao, 266101, China. guojing@qibebt.ac.cn.; Qingdao New Energy Shandong Laboratory, Qingdao, 266101, China. guojing@qibebt.ac.cn., Zhang R; CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China. zhangrb@qibebt.ac.cn.; Shandong Energy Institute, Qingdao, 266101, China. zhangrb@qibebt.ac.cn.; Qingdao New Energy Shandong Laboratory, Qingdao, 266101, China. zhangrb@qibebt.ac.cn.
Jazyk: angličtina
Zdroj: World journal of microbiology & biotechnology [World J Microbiol Biotechnol] 2024 Jan 11; Vol. 40 (2), pp. 68. Date of Electronic Publication: 2024 Jan 11.
DOI: 10.1007/s11274-024-03885-4
Abstrakt: 1,2,4-butanetriol (BT) is a polyol with unique chemical properties, which has a stereocenter and can be divided into D-BT (the S-enantiomer) and L-BT (the R-enantiomer). BT can be used for the synthesis of 1,2,4-butanetriol trinitrate, 3-hydroxytetrahydrofuran, polyurethane, and other chemicals. It is widely used in the military industry, medicine, tobacco, polymer. At present, the BT is mainly synthesized by chemical methods, which are accompanied by harsh reaction conditions, poor selectivity, many by-products, and environmental pollution. Therefore, BT biosynthesis methods with the advantages of mild reaction conditions and green sustainability have become a current research hotspot. In this paper, the research status of microbial synthesis of BT was summarized from the following three aspects: (1) the biosynthetic pathway establishment for BT from xylose; (2) metabolic engineering strategies employed for improving BT production from xylose; (3) other substrates for BT production. Finally, the challenges and prospects of biosynthetic BT were discussed for future methods to improve competitiveness for industrial production.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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