Spatial IMA1 regulation restricts root iron acquisition on MAMP perception.

Autor: Cao M; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., Platre MP; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., Tsai HH; Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland., Zhang L; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., Nobori T; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.; Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA., Armengot L; Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra, Spain.; Department of Genetics, Microbiology and Statistics, Universitat de Barcelona, Barcelona, Spain., Chen Y; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., He W; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., Brent L; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA., Coll NS; Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra, Spain.; Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain., Ecker JR; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.; Genomic Analysis Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.; Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA, USA., Geldner N; Department of Plant Molecular Biology, University of Lausanne, Lausanne, Switzerland., Busch W; Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. wbusch@salk.edu.; Integrative Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA. wbusch@salk.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Jan; Vol. 625 (7996), pp. 750-759. Date of Electronic Publication: 2024 Jan 10.
DOI: 10.1038/s41586-023-06891-y
Abstrakt: Iron is critical during host-microorganism interactions 1-4 . Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity 5 . However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators 6-9 . Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) in Arabidopsis thaliana. This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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